The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridBeytur, Ali/0000-0002-7870-3318;
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.authorwosidÖzgöçer, Tuba/AAA-1751-2021
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorSandal, Suleyman
dc.contributor.authorTekin, Suat
dc.contributor.authorSeker, Fatma Burcu
dc.contributor.authorBeytur, Ali
dc.contributor.authorVardi, Nigar
dc.contributor.authorColak, Cemil
dc.contributor.authorTapan, Tuba
dc.date.accessioned2024-08-04T20:40:21Z
dc.date.available2024-08-04T20:40:21Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractApelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar-Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10 nmol (10 mu l/h) for seven days. At the last 90 min of the infusion period, the blood samples were collected at 15 min intervals (0-90 min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75 min (p <0.05). However, FSH levels did not significantly differ among the groups. Serum testosterone levels in high dose apelin-13 group were statistically lower than the control group (p <0.05). In addition, histological examination showed that infusion of high dose apelin-13 significantly decreased the number of Leydig cells compared with the control and lower dose apelin-13 groups (p < 0.05,p < 0.01). Our results suggest that apelin-13 may play a role in the central regulation and decreases testosterone release by suppressing LH secretion. Thus, antagonists of the apelin receptor may, therefore, be useful for pharmaceuticals in the treatment of infertility. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University BAP [2010/140]en_US
dc.description.sponsorshipThis study was supported by Inonu University BAP (Project # 2010/140).en_US
dc.identifier.doi10.1016/j.neulet.2015.06.059
dc.identifier.endpage138en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid26149233en_US
dc.identifier.scopus2-s2.0-84937573715en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2015.06.059
dc.identifier.urihttps://hdl.handle.net/11616/96872
dc.identifier.volume602en_US
dc.identifier.wosWOS:000360596400025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApelinen_US
dc.subjectFSHen_US
dc.subjectLHen_US
dc.subjectTestosteroneen_US
dc.subjectLeydig cellen_US
dc.subjectReproduction functionen_US
dc.titleThe effects of intracerebroventricular infusion of apelin-13 on reproductive function in male ratsen_US
dc.typeArticleen_US

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