Akut ve kronik ürtiker hastalarında platelet belirteçlerinin, C-reaktif protein düzeyleri ve hastalık şiddeti ile karşılaştırılması
Yükleniyor...
Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Akut ve kronik ürtiker hastalarında rutin hemogram içinde bulunan platelet belirteçlerini ölçerek, hastalık aktivitesi ve serum C-reaktif protein düzeyleri ile karşılaştırmak, ürtiker patogenezinde plateletlerin rolünü araştırmaktır. Gereç ve yöntem: Çalışmamıza yaşları 18-76 arasında değişen 34 akut ürtiker hastası, 27 kronik ürtiker hastası, 30 sağlıklı gönüllü birey alındı. Başvuru anında,hastalığın aktif döneminde ÜAS' ları hesaplandı ve kan örnekleri alındı. Kronik ürtiker hastalarına ek olarak OSDT uygulandı. Bulgular: Gruplar arasında demografik özellikler açısından anlamlı fark saptanmadı. Her üç grupta platelet belirteçlerinden MPV ve PDW değerleri, akut ve kronik ürtiker grupları arasında anlamlı fark olmamasına rağmen, kontrol grubunda bu değerler istatistiksel olarak anlamlı yüksek bulundu (p<0,001). Yine CRP düzeyi, hasta grupları arasında farklı bulunmazken, kontrol grubunda istatistiksel olarak anlamlı düşük bulundu (p=0,008). Kronik ürtiker hasta grubunda OSDT negatif olanlar ile OSDT pozitif olanlar arasında ÜAS, CRP ve platelet belirteçleri açısından anlamlı fark bulunmadı. Sonuç: Ürtiker patogenezinde plateletlerin rolü rolü ve önemini anlamak için, daha geniş hasta serilerinde çalışmalara gereksinim vardır. Anahtar kelimeler: Ürtiker, platelet, C-reaktif protein
Aim: We aimed to measure platelet markers at complete blood count at patients with acute and chronic urticaria and to compare them with disease activity and serum C-reactive protein (CRP) levels in order to search the role of platelets at pathogenesis of urticaria. Material and Method: Total of 34 patients with acute urticaria, 27 patients with chronic urticaria and 30 healthy volunteers whose ages were between 18 and 76 years were enrolled to the study. At the time of application, urticaria activity scores (UAS) were calculated during active period of the disease and blood samples were collected. Autologous serum skin test (ASST) was applied to patients with chronic urticaria. Findings: There was no significant difference between groups in terms of factors. Among platelet markers, there was no statistically significant difference in terms of MPV and PDW values between acute and chronic urticaria groups but these values were statistically significantly higher in control group (p<0.001). Similarly, there was no statistically significant difference in terms of CRP values between acute and chronic urticaria groups where was they were statistically significantly low at control group (p=0.008). At chronic urticaria group, there were no statistically significant differences in terms of UAS, CRP and platelet markers between ASST(+) and ASST(-) patients. Conclusion: More studies with larger patient groups are required in order to comprehend the role and significance of platelets at pathogenesis of urticaria. Keywords: urticaria, platelets, C-reactive protein
Aim: We aimed to measure platelet markers at complete blood count at patients with acute and chronic urticaria and to compare them with disease activity and serum C-reactive protein (CRP) levels in order to search the role of platelets at pathogenesis of urticaria. Material and Method: Total of 34 patients with acute urticaria, 27 patients with chronic urticaria and 30 healthy volunteers whose ages were between 18 and 76 years were enrolled to the study. At the time of application, urticaria activity scores (UAS) were calculated during active period of the disease and blood samples were collected. Autologous serum skin test (ASST) was applied to patients with chronic urticaria. Findings: There was no significant difference between groups in terms of factors. Among platelet markers, there was no statistically significant difference in terms of MPV and PDW values between acute and chronic urticaria groups but these values were statistically significantly higher in control group (p<0.001). Similarly, there was no statistically significant difference in terms of CRP values between acute and chronic urticaria groups where was they were statistically significantly low at control group (p=0.008). At chronic urticaria group, there were no statistically significant differences in terms of UAS, CRP and platelet markers between ASST(+) and ASST(-) patients. Conclusion: More studies with larger patient groups are required in order to comprehend the role and significance of platelets at pathogenesis of urticaria. Keywords: urticaria, platelets, C-reactive protein
Açıklama
Anahtar Kelimeler
Dermatoloji, Dermatology
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Yaşar, D. (2015). Akut ve kronik ürtiker hastalarında platelet belirteçlerinin, C-reaktif protein düzeyleri ve hastalık şiddeti ile karşılaştırılması. Yayımlanmış Uzmanlık Tezi, İnönü Üniversitesi, Malatya.
