Protective effect of resveratrol against oxidative stress in cholestasis

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dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorAra, C
dc.contributor.authorKirimlioglu, H
dc.contributor.authorKarabulut, AB
dc.contributor.authorCoban, S
dc.contributor.authorAy, S
dc.contributor.authorHarputluoglu, M
dc.contributor.authorKirimlioglu, V
dc.date.accessioned2024-08-04T20:14:54Z
dc.date.available2024-08-04T20:14:54Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. We investigated the protective role of resveratrol in rat liver injuries induced by chronic biliary obstruction. Materials and methods. Secondary biliary cirrhosis was induced by bile duct ligation for 28 days. Swiss albino rats were divided into the three following groups: group 1: sham (n = 7); group 2: bile duct ligation (n = 7); group 3: bile duct ligation plus resveratrol (n = 7). Bile duct ligation plus resveratrol group received 10 mg(kg dose of resveratrol intraperitoneally daily for 28 days. Liver damage and cholestasis were determined by the biochemical and the pathologic examination. Results. The present data showed a decrease in both plasma bilirubin levels and aspartate aminotransferase and alanine aminotransferase levels in the resveratrol-treated rats, when compared with bile duct ligation group (P < 0.05). In the resveratrol-treated rats, tissue levels of malondialdehyde and nitric oxide were significantly lower than that of the bile duct ligation (P < 0.002). The levels of glutathione in resveratrol-treated rats were significantly higher than that in bile duct ligation group (P < 0.004). The levels of interleukin-1 alpha, interleukin-6, and tumor necrosis factor-alpha in resveratrol group were significantly lower than that in bile duct ligation group (P < 0.004, P < 0.001, P < 0.001, respectively). Administration of resveratrol in the rats with biliary obstruction resulted in inhibition of ductular proliferation and lymphocytic inflammation. Conclusion. The present study demonstrates that intraperitoneal administration of resveratrol in bile duct ligated rats maintained antioxidant defenses and reduces liver oxidative damage and ductular proliferation. This effect of resveratrol may be useful in the preservation of liver function in cholestasis. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2005.01.024
dc.identifier.endpage117en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid16083749en_US
dc.identifier.scopus2-s2.0-23144457741en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2005.01.024
dc.identifier.urihttps://hdl.handle.net/11616/94036
dc.identifier.volume127en_US
dc.identifier.wosWOS:000231056700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbile duct ligationen_US
dc.subjectbiliary cirrhosisen_US
dc.subjectoxidative stressen_US
dc.subjectductular proliferationen_US
dc.subjectresveratrolen_US
dc.subjectinterleukin-1 alphaen_US
dc.subjectinterleukin-6en_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleProtective effect of resveratrol against oxidative stress in cholestasisen_US
dc.typeArticleen_US

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