Hemolysis, elevated liver enzymes, and low platelet syndrome: Outcomes for patients admitted to intensive care at a tertiary referral hospital

Basit Öğe Kaydı
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridGedik, Ender/0000-0002-7175-207X
dc.authoridcolak, yusuf ziya/0000-0002-8729-8705
dc.authoridKOCA, ERDINC/0000-0002-6691-6711
dc.authoridŞahin, Taylan/0000-0002-9888-6625
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidGedik, Ender/ABI-2971-2020
dc.authorwosidcolak, yusuf ziya/ABH-3032-2020
dc.authorwosidsahin, taylan/IWD-9406-2023
dc.authorwosidKOCA, ERDINC/GSJ-0735-2022
dc.authorwosidŞahin, Taylan/AAT-4038-2020
dc.contributor.authorGedik, Ender
dc.contributor.authorYucel, Neslihan
dc.contributor.authorSahin, Taylan
dc.contributor.authorKoca, Erdinc
dc.contributor.authorColak, Yusuf Ziya
dc.contributor.authorTogal, Turkan
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim was to assess outcomes for pregnancies in which hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome develops and the patient requires transfer for critical care. Materials and Methods: The cases of women with HELLP syndrome who delivered at our tertiary center or surrounding hospitals and were admitted to the intensive care between January 2007 and July 2012 were retrospectively analyzed. Results were compared for the surviving and non-surviving patients. Results: Among the 77 women with HELLP syndrome, maternal mortality rate was 14% and 24 (30%) of 81 fetuses and newborns died in the perinatal period. The most common maternal complications were disseminated intravascular coagulation (DIC) (n = 22; 29%), acute renal failure (n = 19; 25%), and postpartum hemorrhage (n = 16; 21%). Compared with surviving women, the non-surviving women had higher mean international normalized ratio (INR) (p < 0.0001); higher mean serum levels of aspartate aminotransferase (AST) (p < 0.0001); higher alanine aminotransferase (ALT) (p < 0.0001); higher lactate dehydrogenase (LDH) (p < 0.0001), and higher bilirubin (p = 0.040) levels; and lower platelet count (p = 0.005). Conclusion: DIC is a major risk factor for maternal outcome among patients with HELLP syndrome who require intensive care. Low platelet count; high AST, ALT, LDH, INR; and total bilirubin are associated with high mortality risk in this patient group. In addition, low platelet count; low fibrinogen level; prolonged activated thromboplastin time; high INR; and high total bilirubin, LDH, blood urea nitrogen, and creatinine are associated with high risk for complications in this patient group.en_US
dc.identifier.doi10.1080/10641955.2016.1218505
dc.identifier.endpage29en_US
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue1en_US
dc.identifier.pmid27599183en_US
dc.identifier.scopus2-s2.0-84986198926en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1080/10641955.2016.1218505
dc.identifier.urihttps://hdl.handle.net/11616/97497
dc.identifier.volume36en_US
dc.identifier.wosWOS:000395178800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHypertension in Pregnancyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComplicationsen_US
dc.subjectcesarean deliveryen_US
dc.subjectdisseminated intravascular coagulationen_US
dc.subjectintensive care uniten_US
dc.subjectpregnancyen_US
dc.titleHemolysis, elevated liver enzymes, and low platelet syndrome: Outcomes for patients admitted to intensive care at a tertiary referral hospitalen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu