Beneficial effect of caffeic acid phenethyl ester CAPE on hepatocyte damage induced by bile duct ligation an electron microscopic examination
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ultrastruct Pathol
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester
(CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats.
Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation
and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many
degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum
dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial
degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium.
CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.
Açıklama
Anahtar Kelimeler
Bile duct ligation, Caffeic acid phenethyl ester, Cholestasis, Ultrastructure
Kaynak
Ultrastruct Pathol
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
5
Künye
Eşrefoğlu, M. Ara, C. (2010). Beneficial effect of caffeic acid phenethyl ester CAPE on hepatocyte damage induced by bile duct ligation an electron microscopic examination. Ultrastruct Pathol. 34:5, 273-278.
