Beneficial effect of caffeic acid phenethyl ester CAPE on hepatocyte damage induced by bile duct ligation an electron microscopic examination

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dc.authorid109416en_US
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorAra, Cengiz
dc.date.accessioned2017-08-24T11:54:02Z
dc.date.available2017-08-24T11:54:02Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRecently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.en_US
dc.identifier.citationEşrefoğlu, M. Ara, C. (2010). Beneficial effect of caffeic acid phenethyl ester CAPE on hepatocyte damage induced by bile duct ligation an electron microscopic examination. Ultrastruct Pathol. 34:5, 273-278.en_US
dc.identifier.doi10.3109/01913121003788729en_US
dc.identifier.endpage278en_US
dc.identifier.issue5en_US
dc.identifier.startpage273en_US
dc.identifier.urihttp://dx.doi.org/10.3109/01913121003788729
dc.identifier.urihttps://hdl.handle.net/11616/7725
dc.identifier.volume34en_US
dc.language.isoenen_US
dc.publisherUltrastruct Patholen_US
dc.relation.ispartofUltrastruct Patholen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBile duct ligationen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectCholestasisen_US
dc.subjectUltrastructureen_US
dc.titleBeneficial effect of caffeic acid phenethyl ester CAPE on hepatocyte damage induced by bile duct ligation an electron microscopic examinationen_US
dc.typeArticleen_US

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