The clinical significance of QTc dispersion measurement for risk of syncope in patients with aortic stenosis

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dc.authorscopusid6701614367
dc.authorscopusid6603604490
dc.authorscopusid6603105539
dc.authorscopusid22946497000
dc.authorscopusid55907513700
dc.contributor.authorKoşar F.
dc.contributor.authorTando?an I.
dc.contributor.authorHisar I.
dc.contributor.authorAytan Y.
dc.contributor.authorIleri M.
dc.date.accessioned2024-08-04T19:59:33Z
dc.date.available2024-08-04T19:59:33Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: (1) To evaluate the clinical usefulness of QTc dispersion determination in aortic stenosis and (2) to compare the effects of QTc dispersion on the occurrence risk of syncope in aortic stenosis. Background: QT interval dispersion has long been known to be a marker of dispersion of ventricular repolarization and, hence, electrical instability. Additionally, it has been shown that these patients have a propensity to ventricular tachyarrhythmic syncope. Methods: The study included 86 patients with aortic stenosis who underwent left-heart catheterization and coronary angiography during investigation of syncope, as well as 30 control subjects. The patients were characterized with regards to the presence or absence of a history of syncope and the severity of aortic stenosis (the degree of peak transvalvular gradient). In addition, QT dispersion measurements were corrected for heart rate according to Bazett's formula and both were measured. Results: QTc dispersion was greater in patients with aortic stenosis than in the control subjects (60 ± 13 msec vs 38 ± 12 msec, P < 0.001). Similarly, QTc dispersion was greater in the patients with a history of syncope than in the patients with no history of syncope (68 ± 12 msec vs 53 ± 10 msec, P < 0.001). In addition, QTc dispersion values were greater in the patients with a high transvalvular gradient than in the patients with a low transvalvular gradient (65 ± 12 msec vs 50 ± 9 reset, P < 0.001). Multivariate logistic regression analysis showed that only an increased QTc dispersion had significant value for the risk of syncope in aortic stenosis. Conclusions: An increased QTc dispersion increases the occurrence risk for syncope in aortic stenosis. These results suggest that high values of QTc dispersion are a sensitive noninvasive marker for determining the risk for syncope in aortic stenosis.en_US
dc.identifier.doi10.1111/j.1540-8183.2001.tb00353.x
dc.identifier.endpage432en_US
dc.identifier.issn0896-4327
dc.identifier.issue4en_US
dc.identifier.pmid12053497en_US
dc.identifier.scopus2-s2.0-0034854571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1111/j.1540-8183.2001.tb00353.x
dc.identifier.urihttps://hdl.handle.net/11616/90717
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFutura Publishing Company Inc.en_US
dc.relation.ispartofJournal of Interventional Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectangiocardiographyen_US
dc.subjectaorta stenosisen_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdiagnostic valueen_US
dc.subjectelectrocardiogramen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmultivariate analysisen_US
dc.subjectpriority journalen_US
dc.subjectprognosisen_US
dc.subjectQT intervalen_US
dc.subjectrisk assessmenten_US
dc.subjectsyncopeen_US
dc.titleThe clinical significance of QTc dispersion measurement for risk of syncope in patients with aortic stenosisen_US
dc.typeArticleen_US

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