The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

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dc.authorscopusid13204590800
dc.authorscopusid55903323700
dc.authorscopusid7004559930
dc.contributor.authorAltinoz E.
dc.contributor.authorTurkoz Y.
dc.contributor.authorVardi N.
dc.date.accessioned2024-08-04T19:59:05Z
dc.date.available2024-08-04T19:59:05Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats. The rats were divided into four groups. Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05). But acrylamide+NAC administration decreased MDA levels significantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05). GSH levels in liver and small intestine tissues reduced significantly in the acrylamide group (p < 0.05). But acrylamide+NAC administration increased GSH levels significantly in all tissues. Whereas GST activity decreased significantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased significantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05). Liver histopathology showed that the liver epithelial cells were damaged significantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged significantly in the acrylamide group. Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2015_049
dc.identifier.endpage258en_US
dc.identifier.issn0006-9248
dc.identifier.issue4en_US
dc.identifier.pmid25773954en_US
dc.identifier.scopus2-s2.0-84928521784en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage252en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_049
dc.identifier.urihttps://hdl.handle.net/11616/90359
dc.identifier.volume116en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Universityen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectLiveren_US
dc.subjectN-acetylcysteineen_US
dc.subjectOxidative stressen_US
dc.subjectSmall and large intestineen_US
dc.titleThe protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissuesen_US
dc.typeArticleen_US

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