Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidAydemir, Orhan/W-1452-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorDeniz, Nurettin
dc.contributor.authorAydemir, Orhan
dc.contributor.authorGueler, Mete
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorKizirgil, Ahmet
dc.date.accessioned2024-08-04T20:37:53Z
dc.date.available2024-08-04T20:37:53Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we evaluated the efficiency of cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. We compared the findings with the standard dose of ceftazidime (1 mg/0.1 ml). Thirty-six New-Zealand White rabbits were divided into 6 equal groups and were treated with different methods (Group 1 = sham, Group 2 = 0.5 mg/0.1 ml cefepime, Group 3 = 1 mg/0.1 ml cefepime, Group 4 = 2 mg/0.1 ml cefepime, Group 5 = 1 mg/0.1 ml ceftazidime, Group 6 = control). The eyes of rabbits in each group were examined clinically on 1st, 3rd, and 6th day of the experiment. At 6th day, 0.1 ml vitreous humor aspirates were obtained and plated for quantification on the blood agar and the results were expressed as colony-forming unit/ml. Subsequently, the eyeballs were enucleated and the histopathological evaluation was performed. Our findings denoted beneficial effects of cefepime in treatment groups (especially, in Groups 3 and 4). Intravitreal cefepime may be an alternative drug in the treatment of P. aeruginosa endophthalmitis.en_US
dc.identifier.doi10.4103/0301-4738.119457
dc.identifier.endpage527en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.issue9en_US
dc.identifier.pmid24104717en_US
dc.identifier.scopus2-s2.0-84886545007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage525en_US
dc.identifier.urihttps://doi.org/10.4103/0301-4738.119457
dc.identifier.urihttps://hdl.handle.net/11616/96252
dc.identifier.volume61en_US
dc.identifier.wosWOS:000326038400014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCefepimeen_US
dc.subjectceftazidimeen_US
dc.subjectendophthalmitisen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleComparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitisen_US
dc.typeArticleen_US

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