Case report: systemic tuberculosis caused by Mycobacterium bovis in a cat

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridKARABULUT, BURAK/0000-0002-4907-6159
dc.authorwosidAkdeniz İncili, Canan/V-6917-2018
dc.authorwosidDabak, Murat/W-4245-2018
dc.authorwosidEröksüz, Hatice/W-4280-2018
dc.authorwosidTimurkan, Mehmet Ozkan/AAQ-4934-2021
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidKARABULUT, BURAK/V-6913-2018
dc.contributor.authorEroksuz, Yesari
dc.contributor.authorBaydar, Ersoy
dc.contributor.authorOtlu, Baris
dc.contributor.authorDabak, Murat
dc.contributor.authorEroksuz, Hatice
dc.contributor.authorKarabulut, Burak
dc.contributor.authorIncili, Canan Akdeniz
dc.date.accessioned2024-08-04T20:45:38Z
dc.date.available2024-08-04T20:45:38Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundThe diagnosis of previous cases of feline tuberculosis in Turkey has been made based solely on pathological changes without isolation of the causative agent. This case report details the first case of feline tuberculosis in Turkey for which the causative agent (Mycobacterium bovis) was confirmed with microbiological isolation, morphological evaluation, molecular (PCR) characterization and antibiotic sensitivity.Case presentationSystemic tuberculosis was diagnosed via postmortem examination of a 5-year-old stray male cat. Mycobacterium bovis was isolated from the lungs, bronchial and gastrointestinal lymph nodes, kidney and liver. The isolate was defined as M. bovis using the Genotype MTBC assay (Hain Lifescience, Germany), which allows differentiation of species within the Mycobacterium tuberculosis complex with an easy-to-perform reverse hybridization assay.Pathological changes were characterized by multifocal to coalescing granulomatous inflammation in the lungs, liver, lymph nodes and kidneys. Further pathological changes included severe, diffuse, hepatocytic atrophy, periportal fibrosis with lymphohistiocytic infiltration, multifocal lymphohistiocytic interstitial nephritis, mild focal pulmonary anthracosis and mild renal and hepatic amyloidosis. Infection by immunosuppressive viral pathogens including feline herpes virus-1, feline immunodeficiency virus and feline parvovirus virus were ruled out by polymerase chain reaction assay (PCR). The isolated mycobacteria were susceptible to isoniazid, ethambutol, rifampicin or streptomycin.ConclusionDisseminated M. bovis is a rare infection in cats. Involvement of submandibular lymph nodes suggested that primary transmission might have been the oral route in the present case.en_US
dc.identifier.doi10.1186/s12917-018-1759-7
dc.identifier.issn1746-6148
dc.identifier.pmid30611261en_US
dc.identifier.scopus2-s2.0-85059494151en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12917-018-1759-7
dc.identifier.urihttps://hdl.handle.net/11616/98594
dc.identifier.volume15en_US
dc.identifier.wosWOS:000454924400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFeline tuberculosisen_US
dc.subjectPathological findingsen_US
dc.subjectMycobacterium bovisen_US
dc.subjectSystemic involvementen_US
dc.titleCase report: systemic tuberculosis caused by Mycobacterium bovis in a caten_US
dc.typeArticleen_US

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