The role of miRNAs targeting K-ras and APC genes in colorectal cancer

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dc.authoridYilmaz, Nesibe/0000-0002-5527-8507
dc.authoridArıkan, Soykan/0000-0001-7132-6161
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridergen, arzu/0000-0001-5736-8453
dc.authorwosidYilmaz, Nesibe/JFK-5834-2023
dc.authorwosidAksakal, Nihat/ABB-5338-2020
dc.authorwosidArıkan, Soykan/HKF-1086-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidergen, arzu/P-6554-2019
dc.contributor.authorYilmaz, N.
dc.contributor.authorYilmaz, U.
dc.contributor.authorTanbek, K.
dc.contributor.authorArikan, S.
dc.contributor.authorAksakal, N.
dc.contributor.authorZeybek, U.
dc.contributor.authorErgen, A.
dc.date.accessioned2024-08-04T20:48:45Z
dc.date.available2024-08-04T20:48:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVES: The occurrence of abnormal expression patterns in different types of cancer suggests that micro RNAs (miRNAs) may play an important role in tumorigenesis. The aim of this study was to examine the expression levels of miRNAs known to be associated with the regulation of the expression levels of the APC and K-ras, which are important in the development of colorectal cancer (CRC). METHODS: The expression levels of miR-27, miR-663, miR-217, miR-181d, APC and K-ras in the serum, tumor and adjacent tumor-free (healthy) tissues of the patients and serum of the healthy controls were investigated with qRT-PCR. RESULTS: Expression levels of miR-217, mR-181d, miR-663, miR-27 and K-ras were found to be higher in CRC tissues than in adjacent tumor-free tissues of the patients. In patient serum samples, miR-663 levels were statistically more elevated than in controls. In patient tumor tissues, miR-217, miR-181d and miR-27 expressions were found to be higher. CONCLUSIONS: Increased miR-181d and miR-217 expression levels are associated with increased K-ras expression in the tumor tissues, and the expression of K-ras, which takes part as an oncogene in the CRC development, might be regulated by these miRNAs (Tab. 4, Ref. 33). Text in PDF www.elis.sken_US
dc.description.sponsorshipResearch Fund of Istanbul University [20707]en_US
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University (Project No. 20707).en_US
dc.identifier.doi10.4149/BLL_2020_092
dc.identifier.endpage557en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8en_US
dc.identifier.pmid32726117en_US
dc.identifier.scopus2-s2.0-85088829844en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_092
dc.identifier.urihttps://hdl.handle.net/11616/99435
dc.identifier.volume121en_US
dc.identifier.wosWOS:000571574800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcolorectalen_US
dc.subjectcanceren_US
dc.subjectmiRNAen_US
dc.subjectAPCen_US
dc.subjectK-rasen_US
dc.titleThe role of miRNAs targeting K-ras and APC genes in colorectal canceren_US
dc.typeArticleen_US

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