Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia-reperfusion necrosis in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorOzhan, Onural
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T20:48:55Z
dc.date.available2024-08-04T20:48:55Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial ischemia may occur as a result of pathophysiological and therapeutical applications such as atherosclerosis, thromboembolism, percutaneous transluminal coronary angioplasty, coronary artery bypass, and transplantation. In this study, we aimed to compare the effects of angiotensin (Ang) II type 2 (AT(2)) selective receptor agonist Compound 21 (C21), MAS receptor agonist AVE 0991, Ang II type 1 (AT(1)) selective receptor blocker losartan, and Ang-converting enzyme inhibitor captopril on haemodynamic parameters and infarct size on myocardial ischemia/reperfusion (MI/R)-induced necrosis in rats. To induce necrosis in the heart of rats, reperfusion for 2 h following ischemia for 30 min to the descending branch of the left main coronary artery was achieved. C21 (0.03 mg/kg), AVE 0991 (576 mu g/kg), losartan (2 mg/kg), and captopril (3 mg/kg) were administered as an intravenous infusion at 10 min before and throughout the ischemia. Then, the infarct size and risk area were calculated from the heart. The percentage of myocardial infarct size to area at risk ratio (%IS/AR) of groups was Control (MI/R) group: 48.9 +/- 8.8%; C21 group: 31.1 +/- 7.8%; AVE 0991 group: 29.9 +/- 4.8%; C21 + AVE 0991 group: 28.2 +/- 3.3%; Losartan + AVE 0991 group: 30.8 +/- 5.8%; Captopril + AVE 0991 group: 31.7 +/- 7.7%. %IS/AR of the drug-treated groups decreased significantly when compared to the MI/R group (P < 0.05). Our results indicate that the importance of AT(1), AT(2), and MAS receptors in the MI/R injury. Inhibition of Ang II formation by captopril, blockade of AT(1)receptor with losartan, and stimulation of AT(2)receptor with C21 and MAS receptor with AVE 0991 showed beneficial effects by reducing infarct size.en_US
dc.description.sponsorshipResearch Fund of the Inonu University [TDK-2017-706]en_US
dc.description.sponsorshipThis work was supported by Research Fund of the Inonu University. Project Number: TDK-2017-706. The authors would like to thank Anders Ljunggren (Vicore Pharma AB, Goteborg, Sweden) for providing C21.en_US
dc.identifier.doi10.1111/fcp.12599
dc.identifier.endpage680en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue4en_US
dc.identifier.pmid32810901en_US
dc.identifier.scopus2-s2.0-85090782674en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage669en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12599
dc.identifier.urihttps://hdl.handle.net/11616/99534
dc.identifier.volume35en_US
dc.identifier.wosWOS:000567803300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAVE 0991en_US
dc.subjectcaptoprilen_US
dc.subjectcompound 21en_US
dc.subjectlosartanen_US
dc.subjectmyocardial ischemia-reperfusion injuryen_US
dc.titleComparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia-reperfusion necrosis in ratsen_US
dc.typeArticleen_US

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