The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group study

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dc.authoridYILMAZ, Mesut/0000-0003-1466-3887
dc.authoridDoğan, İzzet/0000-0003-1018-1119
dc.authoridAkin Telli, Tugba/0000-0001-6535-6030
dc.authoridKivrak Salim, Derya/0000-0003-4107-3460
dc.authoridDiker, Omer/0000-0001-7162-4812
dc.authoridgülmez, ahmet/0000-0002-3353-344X
dc.authoridAktürk Esen, Selin/0000-0002-3426-9505
dc.authorwosidYILMAZ, Mesut/AAV-1726-2020
dc.authorwosidDoğan, İzzet/AAB-6635-2020
dc.authorwosidAkin Telli, Tugba/GSE-4006-2022
dc.authorwosidKivrak Salim, Derya/A-3920-2015
dc.authorwosidVatansever, Sezai/AAY-8457-2020
dc.authorwosidAykan, Musa Barış/AEK-4253-2022
dc.authorwosidmustafa, Muhammed/HME-1300-2023
dc.contributor.authorOzdemir, Ozlem
dc.contributor.authorZengel, Baha
dc.contributor.authorYildiz, Yasar
dc.contributor.authorUluc, Basak Oyan
dc.contributor.authorCabuk, Devrim
dc.contributor.authorOzden, Ercan
dc.contributor.authorSalim, Derya Kivrak
dc.date.accessioned2024-08-04T20:52:09Z
dc.date.available2024-08-04T20:52:09Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab to the treatment of HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by the Turkish Oncology Group (TOG) with data collected from 32 centers. Our study was multicentric, and a total of 364 patients were included. The median age of the patients was 49 years (18-85 years). Two hundred fifteen (60%) of the cases were hormone receptor/HER2+ positive(ER+ or PR+, or both), and 149 (40%) of them were HER2-rich (ER and PR negative). The number of complete responses was 124 (54%) in the docetaxel+trastuzumab+pertuzumab arm and 102 (45%) in the paclitaxel+trastuzumab+pertuzumab arm, and there was no difference between the groups in terms of complete response. In 226 (62%) patients with complete response, a significant correlation was found with DCIS, tumor focality, removed lymph node, and ER status P < 0.05. Anemia, nausea, vomiting, myalgia, alopecia, and mucosal inflammation were significantly higher in the docetaxel arm, P < 0.05. In our study, no statistical difference was found between the before-after echocardiography values. DCIS positivity in biopsy before neoadjuvant chemotherapy, tumor focality; the number of lymph nodes removed and ER status were found to be associated with pCR. In conclusion, we think that studies evaluating pCR-related clinicopathological variables and radiological imaging features will play a critical role in the development of nonsurgical treatment approaches.en_US
dc.identifier.doi10.1097/CAD.0000000000001310
dc.identifier.endpage670en_US
dc.identifier.issn0959-4973
dc.identifier.issn1473-5741
dc.identifier.issue7en_US
dc.identifier.pmid35703239en_US
dc.identifier.scopus2-s2.0-85134433317en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://doi.org/10.1097/CAD.0000000000001310
dc.identifier.urihttps://hdl.handle.net/11616/100791
dc.identifier.volume33en_US
dc.identifier.wosWOS:000824584100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnti-Cancer Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast canceren_US
dc.subjectneoadjuvant chemotherapyen_US
dc.subjectpathological responseen_US
dc.subjectpertuzumaben_US
dc.titleThe effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group studyen_US
dc.typeArticleen_US

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