Evaluation of left atrial volume and functions by 3D echocardiography in patients with prediabetes and investigation of its correlation with NT-pro ANP levels

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dc.contributor.authorEyyüpkoca, Ferhat
dc.contributor.authorHidayet, Siho
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorBayramoğlu, Adil
dc.contributor.authorAltıntaş, Mehmet Sait
dc.contributor.authorAkaycan, Julide
dc.date.accessioned2024-08-04T19:53:27Z
dc.date.available2024-08-04T19:53:27Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: An increased burden of cardiovascular disease is observed in prediabetes compared to normoglycemic. In this study, we aimed to evaluate left atrium (LA) volume indices and mechanical functions in prediabetes patients by real-time three- dimensional echocardiography (3DE) and examine the relationship of these parameters with N-terminal pro-atrial natriuretic peptide (NT-pro-ANP) levels. Methods: 41 patients diagnosed with prediabetes by the oral glucose tolerance test in the endocrinology outpatient clinic and 43 healthy controls were included in this study. We evaluated the volume indices and mechanical functions of the LA using 3DE. Plasma NT-proANP was evaluated by the enzyme-linked immunosorbent assay method. Results: Median NT-pro-ANP level was higher in the prediabetes group than the control group (1.5 vs 0.7 nmol/L, p<0.001). Levels of LA volume index (LAVI), minimum and maximum of LA volume (Vmin, Vmax; respectively), pre- atrial contraction volume (VpreA), active emptying fraction, and total and active emptying volume, each reflects reservoir and pump functions of LA, were higher in the prediabetes group. In contrast, the LA passive emptying fraction (PEF) level was lower (p<0.05). There was a positive correlation between levels of NT-pro-ANP and Vmax (r= 0.352, p=0.024), Vmin (r= 0.563, p<0.001), VpreA (r= 0.504, p<0.001), and LAVI (r= 0.338, p=0.031), while negative correlation existed between levels of NT-pro-ANP and total emptying fraction (r = -0.522, p<0.001) and PEF (r= -0.349, p=0.025) was found. Conclusion: LA volume and mechanical functions are impaired in prediabetes patients, and this deterioration was positively correlated with NT pro-ANP levels. The current findings demonstrate that cardiac structural deterioration in prediabetes patients is just initiated before overt diabetes onset.en_US
dc.identifier.doi10.54307/NWMJ.2022.33043
dc.identifier.endpage50en_US
dc.identifier.issn2757-7724
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.trdizinid1175286en_US
dc.identifier.urihttps://doi.org/10.54307/NWMJ.2022.33043
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175286
dc.identifier.urihttps://hdl.handle.net/11616/89783
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNorthwestern Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of left atrial volume and functions by 3D echocardiography in patients with prediabetes and investigation of its correlation with NT-pro ANP levelsen_US
dc.typeArticleen_US

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