5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature review

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dc.contributor.authorElboga, Gulcin
dc.contributor.authorAksoy, Perihan Gizem
dc.contributor.authorKus, Tulay
dc.contributor.authorKarayagmurlu, Elif
dc.contributor.authorAktas, Gokmen
dc.contributor.authorSahin, Sengul
dc.contributor.authorAltindag, Abdurrahman
dc.date.accessioned2022-03-01T12:30:41Z
dc.date.available2022-03-01T12:30:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe combination of 5-fluorouracil (5-FU), irinotecan and bevacizumab (FOLFIRI-beva) is one of the main treatment options for metastatic colon cancer. We present a rare case of irritable mood elevation during FOLFIRI-beva treatment in a man without psychiatric history. A 41-year-old man with colon cancer developed a manic episode after four cycles of chemotherapy. After excluding the other causes, the patient was diagnosed with Medication-induced Bipolar disorder manic episode with mixed features according to the criteria of Diagnostic and Statistical Manual of Mental Disorders, fifth edition. Chemotherapy was discontinued, and antipsychotic treatment with haloperidol and biperidone was started. He recovered after 12 days. While adjustment disorders, depression and delirium are more common in cancer patients, mood disorders are rare during chemotherapy. Neuropsychiatric manifestations are uncommon during 5-FU treatment. Clinicians should keep in mind that a neuropsychological condition or mood disorders may be encountered during chemotherapy especially with 5-FU.en_US
dc.identifier.citationElboga, G., Gizem Aksoy, P., Kus, T., Karayagmurlu, E., Aktas, G., Sahin, S., & Altindag, A. (2021). 5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature review . Annals of Medical Researchen_US
dc.identifier.urihttps://hdl.handle.net/11616/54126
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.title5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature reviewen_US
dc.typeArticleen_US

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