Antioxidative effects of novel synthetic organoselenium compound in rat lung and kidney

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorGok, Yetkin
dc.date.accessioned2024-08-04T20:31:07Z
dc.date.available2024-08-04T20:31:07Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of environmental chemicals, drugs, and physical agents on the developing lung and kidney are influenced by the state of development and maturation. Selenium is an essential element with physiological nonenzymatic antioxidant properties. Therefore, we undertook the present study to evaluate the antioxidant potential of the novel synthetic organoselenium compounds (Se I and Se II). In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds [1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1,3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in the determined doses. The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)] parameters in rat lung and kidney were investigated. As a result, it was found that both Se I and Se II had provided the antioxidant effects against DMBA-induced oxidative stress in rat lung and kidney and lipid peroxidation had also been decreased by these organoselenium compounds. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [TBAG-2259, 102T185]en_US
dc.description.sponsorshipWe thank to Technological and Scientific Research Council of Turkey TUBITAK TBAG-2259 (102T185) for financial support of this work.en_US
dc.identifier.doi10.1016/j.ecoenv.2007.11.012
dc.identifier.endpage921en_US
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.issue3en_US
dc.identifier.pmid18222543en_US
dc.identifier.scopus2-s2.0-59149083390en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage916en_US
dc.identifier.urihttps://doi.org/10.1016/j.ecoenv.2007.11.012
dc.identifier.urihttps://hdl.handle.net/11616/94742
dc.identifier.volume72en_US
dc.identifier.wosWOS:000263762100036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDMBAen_US
dc.subjectKidneyen_US
dc.subjectLungen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectSynthetic organoselenium compoundsen_US
dc.titleAntioxidative effects of novel synthetic organoselenium compound in rat lung and kidneyen_US
dc.typeArticleen_US

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