Evaluation of Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry and Biochemical Markers

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.contributor.authorSarici, Kemal Baris
dc.contributor.authorAkbulut, Sami
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorGarzali, Ibrahim Umar
dc.contributor.authorKucukakcali, Zeynep
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:53:40Z
dc.date.available2024-08-04T20:53:40Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim. This study aimed to evaluate the course of bone and mineral metabolism after liver trans-plantation (LT) in patients with chronic liver disease.Methods. One hundred four patients who had undergone LT and had a minimum of 6 months of follow-up after LT were included in this prospective cohort study. The following parameters were evaluated for each patient: preoperative and postoperative (postoperative day [POD]30, POD90, POD180) osteocalcin, bone-specific alkaline phosphatase (BALP), type 1 collagen, beta-C-terminal end telopeptide (b-CTx), vitamin D, parathyroid hormone (PTH), ALP, calcium, phosphate, sedimentation, and bone mineral densitometer scores (L2, L4, L total, and F total). The parameters were compared in terms of sex, presence of liver tumor (hepatocellular carci-noma [HCC; n = 19] vs non-HCC [n = 85]), and presence of autoimmune liver disease (autoim-mune liver disease [ALD; n = 8] vs non-ALD [n = 96]). Results. The median age of the patients (n = 81 men and n = 23 women) was 52 years (95% CI, 50-56). There was a significant change in the defined time intervals in parameters such as osteocalcin (P < .001), BALP (P < .001), b-CTx (P < .001), vitamin D (P < .001), PTH (P < .001), ALP (P = .001), calcium (P < .001), phosphate (P = .001), L2 (P = .038), L total (P = .026), and F total (P < .001) scores. There was a significant difference in POD90 ALP (P = .033), POD180 calcium (P = .011), POD180 phosphate (P = .011), preoperative sedimentation (P = .032), and POD180 F total (P = .013) scores between both sexes. There was a significant difference in POD180 osteocalcin (P = .023), POD180 b-CTx (P = .017), and preOP calcium (P = .003) among the HCC and non-HCC groups. Furthermore, we found significant differences in preoperative ALP (P = .008), preop-erative sedimentation (P = .019), POD90 (P = .037) and POD180 L2 (P = .005) scores, preoperative (P = .049) and POD180 L4 (P = .017), and POD180 L total (P = .010) and F total (P = .022) scores between the patients with and without ALD. Conclusion. This study shows that the bone and mineral metabolism of the LT recipients was negatively affected after LT. In addition, we showed that bone and mineral metabolism was more prominent in patients with HCC, and bone mineral density scores were higher in patients with ALD.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2018-1312]en_US
dc.description.sponsorshipACKNOWLEDGMENTS This study was supported by Inonu University Scientific Research Projects Coordination Unit (Project TSA-2018-1312) .en_US
dc.identifier.doi10.1016/j.transproceed.2023.03.034
dc.identifier.endpage1244en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid37127514en_US
dc.identifier.scopus2-s2.0-85153857499en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1239en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2023.03.034
dc.identifier.urihttps://hdl.handle.net/11616/101322
dc.identifier.volume55en_US
dc.identifier.wosWOS:001033439000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectTurnoveren_US
dc.subjectFractureen_US
dc.subjectDiseaseen_US
dc.titleEvaluation of Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry and Biochemical Markersen_US
dc.typeArticleen_US

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