Assessment of clinical phenotypic characteristics of patients with angioedema without wheals in a turkish population

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dc.authoridçakmak, mehmet erdem/0000-0001-7899-3004
dc.authorwosidçakmak, mehmet erdem/HKE-5620-2023
dc.contributor.authorCakmak, Mehmet Erdem
dc.contributor.authorBostan, Ozge Can
dc.contributor.authorKaya, Saltuk Bugra
dc.contributor.authorKarakaya, Gul
dc.contributor.authorKalyoncu, Ali Fuat
dc.contributor.authorDamadoglu, Ebru
dc.date.accessioned2024-08-04T20:56:12Z
dc.date.available2024-08-04T20:56:12Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Angioedema (AE) is defined fi ned as localized, self-limited swelling of subcutaneous tissues and mucosa. Objective: The aim of this study was to compare the phenotypic characteristics of patients with AE without wheals. Methods: This prospective study included adult patients with recurrent AE without wheals. Demographic and laboratory data of the patients were recorded in the patient fi le when they presented to the outpatient clinic between August 2018 and August 2020. The patients were contacted by phone to evaluate whether their AE had gone into remission between October 2023 and January 2024. The phenotypic characteristics of AE subtypes were compared. Results: The study included a total of 143 patients. The average age, age of onset of AE, rates of diabetes mellitus, hypertension and coronary artery disease were higher in the patients with angiotensin-converting enzyme inhibitor (ACEI) use related acquired AE (AAE) (AAE-ACEI). The rates of allergic rhinitis, drug allergy, atopy, and aeroallergen sensitivity, and the median total immunoglobulin E level were higher in patients with idiopathic histaminergic AAE (AAE-IH). The rate of face and/or perioral AE attacks was higher in the patients with AAE-ACEI, AAE-IH, and idiopathic non-histaminergic AAE. The rate of AE attacks in limbs, abdominal, genital and other parts of the body was higher in patients with hereditary AE (HAE). The baseline AE activity score was lower in the patients with AAE-IH and higher in the patients with HAE. In longterm follow-up, the remission rate of AE attacks was significant fi cant higher in patients with AAE-ACEI and AAE-IH. Conclusion: The phenotypic characteristic features of Turkish patients with AE without wheals may vary, depending on the underlying AE pathogenesis. C1 inhibitor level and function, complement C4 and C1q, and genetic tests contributed to the diagnosis; other laboratory tests did not contribute to the diagnosis.en_US
dc.identifier.doi10.2500/aap.2024.45.240034
dc.identifier.endpage246en_US
dc.identifier.issn1088-5412
dc.identifier.issn1539-6304
dc.identifier.issue4en_US
dc.identifier.pmid38982609en_US
dc.identifier.scopus2-s2.0-85198495103en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.2500/aap.2024.45.240034
dc.identifier.urihttps://hdl.handle.net/11616/102119
dc.identifier.volume45en_US
dc.identifier.wosWOS:001267352700010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOcean Side Publications Incen_US
dc.relation.ispartofAllergy and Asthma Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClassificationen_US
dc.subjectManagementen_US
dc.subjectUrticariaen_US
dc.subjectDiagnosisen_US
dc.titleAssessment of clinical phenotypic characteristics of patients with angioedema without wheals in a turkish populationen_US
dc.typeArticleen_US

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