The effects of enalapril maleate and cold stress exposure on tyrosine hydroxylase activity in some rat tissues

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dc.authorscopusid23471088100
dc.authorscopusid6602072091
dc.contributor.authorTalas Z.S.
dc.contributor.authorYurekli M.
dc.date.accessioned2024-08-04T19:59:21Z
dc.date.available2024-08-04T19:59:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEnalapril is a highly specific and competitive inhibitor of angiotensin-I converting enzyme (ACE) and thus belongs to the category of ACE inhibitors. The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldesterone system. This study was designed to detect the effects of enalapril maleate and cold stress on tyrosine hydroxylase (TH) activity in adrenal medulla, heart and hypothalamus in rat. In cold stress treatment (exposed to 8°C cold for 48 h) TH activity was found to be raised significantly (p < 0.05) in adrenal medulla, hypothalamus and heart tissues. In the adrenal medulla, hypothalamus and heart tissues, TH activity of enalapril maleate treated rats (10 mg kg-1 body weight) group was not raised significantly (p > 0.05). Following intraperitoneal injection of enalapril maleate (10 mg kg-1 body weight) the rats were exposed to 8°C cold for 48 h. After cold stress and enalapril maleate treatment no statistically significant change in tyrosine hydroxylase activity was detected in adrenal medulla, hypothalamus or heart (p > 0.05). The results of our studies show that enalapril maleate blocks the effect of cold stress on the regulation of TH activity. Copyright © 2005 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1256
dc.identifier.endpage540en_US
dc.identifier.issn0263-6484
dc.identifier.issue6en_US
dc.identifier.pmid16149109en_US
dc.identifier.scopus2-s2.0-33751196997en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1256
dc.identifier.urihttps://hdl.handle.net/11616/90555
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold stressen_US
dc.subjectEnalapril maleateen_US
dc.subjectRaten_US
dc.subjectTyrosine hydroxylaseen_US
dc.titleThe effects of enalapril maleate and cold stress exposure on tyrosine hydroxylase activity in some rat tissuesen_US
dc.typeArticleen_US

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