Evaluation of Serum Thiamine and Pyridoxine Levels in Patients Undergoing Liver Transplant: A Prospective Study

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorAkbulut, Sami
dc.contributor.authorAbbasov, Parviz
dc.contributor.authorKarakas, Serdar
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:50:15Z
dc.date.available2024-08-04T20:50:15Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: This prospective study aimed to compare changes in serum thiamine and pyridoxine levels of patients who underwent liver transplant or living donor hepatectomy. Materials and Methods: Between January 2013 and November 2013, 35 patients with chronic liver disease who underwent liver transplant (the recipient group) and 30 healthy individuals who underwent living donor hepatectomy (the control group) during the same period were prospectively compared in terms of both preoperative and postoperative serum thiamine and pyridoxine levels. The groups were also subjected to intragroup analysis of preoperative and postoperative changes in serum vitamin levels to determine how a major surgical procedure affected serum vitamin levels. Mann-Whitney U test and Wilcoxon signed-rank test were used for intergroup comparisons and intragroup repeated measurements, respectively. Results: The intergroup comparisons revealed significant differences in favor of the control group with respect to preoperative thiamine (P < .026) and postoperative thiamine (P < .017) levels, whereas there were statistically significant differences in favor of the recipient group with respect to the preoperative pyridoxine (P < .006) and postoperative pyridoxine (P < .001) levels. The intragroup comparisons showed significant increases in serum thiamine (P < .001) and pyridoxine (P < .031) levels compared with the preoperative serum levels of both vitamins at postoperative day 5 in the recipient group. In the control group, serum thiamine level (P < .001) at postoperative day 5 was significantly different from the preoperative level. On the other hand, a drop in serum pyridoxine level was detected at postoperative day 5, although this was not statistically significant (P < .21). Conclusions: This study showed a lower serum thiamine level but a higher serum pyridoxine level in patients with chronic liver disease versus healthy controls. This difference persisted into the early postoperative period. This study also showed significant increases in thiamine and pyridoxine levels after transplant surgery.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit (Malatya, Turkey)en_US
dc.description.sponsorshipThis study was financially supported by the Inonu University Scientific Research Projects Coordination Unit (Malatya, Turkey). The authors declare that they have no conflicts of interest.en_US
dc.identifier.doi10.6002/ect.2017.0102
dc.identifier.endpage461en_US
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue5en_US
dc.identifier.pmid29292683en_US
dc.identifier.scopus2-s2.0-85106464128en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2017.0102
dc.identifier.urihttps://hdl.handle.net/11616/99953
dc.identifier.volume19en_US
dc.identifier.wosWOS:000647569000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic liver diseaseen_US
dc.subjectLiver transplantationen_US
dc.subjectLiving donor hepatectomyen_US
dc.subjectMetabolismen_US
dc.titleEvaluation of Serum Thiamine and Pyridoxine Levels in Patients Undergoing Liver Transplant: A Prospective Studyen_US
dc.typeArticleen_US

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