Associations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitus

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dc.authoridBULMUŞ, FUNDA GÜLCÜ/0000-0002-2514-4559
dc.authoridAKYOL, ALPASLAN/0000-0001-5089-8961
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridGURSU, M.Ferit/0000-0003-3552-7315
dc.authorwosidgürsu, mehmet/HJZ-1663-2023
dc.authorwosidBULMUŞ, FUNDA GÜLCÜ/V-9326-2018
dc.authorwosidAKYOL, ALPASLAN/W-7521-2018
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidGURSU, M.Ferit/V-6898-2017
dc.contributor.authorBagci, H.
dc.contributor.authorMelekoglu, R.
dc.contributor.authorGursu, M. F.
dc.contributor.authorAkyol, A.
dc.contributor.authorBulmus, F. G.
dc.date.accessioned2024-08-04T20:45:23Z
dc.date.available2024-08-04T20:45:23Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Gestational diabetes mellitus (GDM) is defined as a glucose intolerance firstly diagnosed during pregnancy. In this study, the authors aimed to investigate the association between serum adiponectin, and resistin levels with insulin resistance and metabolic parameters in patients with GDM. Material and Methods: A total of 80 patients: 40 healthy pregnant women (control group) and 40 pregnant women diagnosed with GDM (study group) were included in this study. Serum adiponectin, resistin, glucose, insulin, HbA1c levels, and lipid parameters were measured. Insulin resistance index HOMA-IR values were calculated. Results: Serum adiponectin levels were detected to be significantly lower (p < 0.001), whereas serum resistin levels were found to be significantly higher (p = 0.004) in GDM group compared with the control group. Levels of HDL-C, LDL-C, VLDL-C, and triglycerides were similar in both groups, but the total cholesterol level was significantly higher in the GDM group (p = 0.013). In the GDM group, adiponectin levels were negatively correlated with HbA1c levels (r = -0.368; p = 0.010) but were not correlated with any other parameter. A significant positive correlation was evident between resistin levels and both total cholesterol (r = 0.476, p = 0.001), and LDL-cholesterol (r = 0.293; p = 0.033). Conclusion: The results of this study demonstrated that serum resistin levels were significantly higher and serum adiponectin levels were significantly lower in pregnant women with GDM patients compared with normoglycemic pregnants. Also, it was detected that there was no correlation between serum adiponectin and resistin levels and insulin resistance in GDM patients.en_US
dc.identifier.doi10.12891/ceog4348.2018
dc.identifier.endpage543en_US
dc.identifier.issn0390-6663
dc.identifier.issn2709-0094
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85052560705en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.12891/ceog4348.2018
dc.identifier.urihttps://hdl.handle.net/11616/98448
dc.identifier.volume45en_US
dc.identifier.wosWOS:000444384300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherImr Pressen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdiponectinen_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectInsulin resistanceen_US
dc.subjectResistinen_US
dc.titleAssociations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitusen_US
dc.typeArticleen_US

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