Combination of allopurinol and hyperbaric oxygen therapy
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Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pancreas
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM: To investigate the individual and combined
effects of allopurinol and hyperbaric oxygen (HBO)
therapy on biochemical and histopathological changes,
oxidative stress, and bacterial translocation (BT) in the
experimental rat acute pancreatitis (AP).
METHODS: Eighty-five Sprague-Dawley rats were
included in the study. Fifteen of the eighty-five rats
were used as controls (sham, GroupⅠ). AP was induced
via intraductal taurocholate infusion in the remaining
seventy rats. Rats that survived to induction of acute
necrotizing pancreatitis were randomized into four
groups. Group Ⅱ received saline, Group Ⅲ allopurinol,
Group Ⅳ allopurinol plus HBO and Group Ⅴ HBO alone.
Serum amylase levels, oxidative stress parameters, BT
and histopathologic scores were determined.
RESULTS: Serum amylase levels were lower in Groups
Ⅲ, Ⅳ and Ⅴ compared to Group Ⅱ (974 ± 110,
384 ± 40, 851 ± 56, and 1664 ± 234 U/L, respectively,
P < 0.05, for all). Combining the two treatment optionsrevealed significantly lower median [25-75 percentiles]
histopathological scores when compared to individual
administrations (13 [12.5-15] in allopurinol group, 9.5
[7-11.75] in HBO group, and 6 [4.5-7.5] in combined
group, P < 0.01). Oxidative stress markers were
significantly better in all treatment groups compared to
the controls. Bacterial translocation into the pancreas
and mesenteric lymph nodes was lower in Groups Ⅲ, Ⅳ
and Ⅴ compared to Group Ⅱ (54%, 23%, 50% vs 100%
for translocation to pancreas, and 62%, 46%, 58% vs
100% for translocation to mesenteric lymph nodes,
respectively, P < 0.05 for all).
CONCLUSION: The present study confirms the benefit
of HBO and allopurinol treatment when administered
separately in experimental rat AP. Combination of these
treatment options appears to prevent progression of
pancreatic injury parameters more effectively.
Açıklama
Anahtar Kelimeler
Experimental pancreatitis, Allopurinol, Hyperbaric oxygen
Kaynak
Pancreas
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
46
Künye
Cömert, B. Işık, A. T. Aydın, S. Bozoğlu, E. Ünal, B. Deveci, S. Mas, N. Çınar, E. Mas, M. R. (2008). Combination of allopurinol and hyperbaric oxygen therapy. Pancreas. 13(46): 6203-6207.
