Protective effects of caffeic acid phenethyl ester on rotenone-induced myocardial oxidative injury

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dc.authoridAkpinar, Mehmet Besir/0000-0002-4220-8390;
dc.authorwosidAkpinar, Mehmet Besir/GLS-3733-2022
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.contributor.authorAkpinar, MB
dc.contributor.authorErdogan, H
dc.contributor.authorSahin, S
dc.contributor.authorUcar, F
dc.contributor.authorIlhan, A
dc.date.accessioned2024-08-04T20:14:47Z
dc.date.available2024-08-04T20:14:47Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRotenone, an insecticide, causes toxicity through inhibition of mitochondrial electron transport chain at complex I and oxidative injury to the tissues. The aim of the present study was to determine in vivo effects of rotenone on myocardium and cardio-protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, against rotenone toxicity in rats. The rats were divided into three groups: untreated control, rotenone (2.5 mg/kg/day for 60 days, i.p.) and rotenone + CAPE groups. CAPE was administrated i.p. 10 ltmol/kg/day for 62 days started two days before first dose rotenone injection. The malondialdehyde, nitric oxide levels and xanthine oxidase activity of rotenone group was significantly higher than control and rotenone + CAPE groups (to < 0.05). However, catalase activity in the rotenone group was decreased in comparison with the other groups (p < 0.05). The superoxide dismutase activity of rotenone group was insignificantly decreased compared to the others. In conclusion, rotenone caused lipid peroxidation in myocardial tissue and CAPE treatment prevented this rotenone-induced lipid peroxiclation in rats. CAPE might be a cardio-protective agent against myocardial toxicities. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pestbp.2005.03.003
dc.identifier.endpage239en_US
dc.identifier.issn0048-3575
dc.identifier.issn1095-9939
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-20644448596en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1016/j.pestbp.2005.03.003
dc.identifier.urihttps://hdl.handle.net/11616/93972
dc.identifier.volume82en_US
dc.identifier.wosWOS:000230049000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofPesticide Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrotenoneen_US
dc.subjecthearten_US
dc.subjectoxidants/antioxidantsen_US
dc.subjectlipiden_US
dc.subjectperoxidationen_US
dc.subjectnitric oxideen_US
dc.subjectCAPEen_US
dc.titleProtective effects of caffeic acid phenethyl ester on rotenone-induced myocardial oxidative injuryen_US
dc.typeArticleen_US

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