Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study

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dc.authoridcankaya, cem/0000-0002-7716-0438
dc.authorwosidCankaya, Cem/HTR-3803-2023
dc.authorwosidcankaya, cem/ABH-6458-2020
dc.contributor.authorDoganay, S.
dc.contributor.authorCankaya, C.
dc.contributor.authorAlkan, A.
dc.date.accessioned2024-08-04T20:36:04Z
dc.date.available2024-08-04T20:36:04Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose To determine whether metabolite changes at cellular level occur in vitreous and lateral geniculate body (LGB) in patients with glaucoma by magnetic resonance spectroscopy (MRS). Methods A total of 29 eyes of 29 patients with glaucoma, no existing ocular pathology and systemic disease (group 1), and 13 eyes of 13 healthy individuals whose routine ophthalmological examinations were normal (group 2) were included in the study. Single-voxel MRS examination was performed by placing region of interest in vitreous and LGB. Glutamate-glutamine (Glx)/creatin (Cr) ratios and lactate peaks in the vitreous, and the Glx/Cr, N-acetyl aspartate (NAA)/Cr, choline (Cho)/Cr ratios in the ipsilateral area of LGB were evaluated. Results A statistically significant difference was found between the two groups for the Glx/Cr ratio in both the vitreous and LGB (P = 0.0001). There was no statistically significant difference between the two groups for the NAA/Cr, and Cho/Cr ratios in the LGB (P = 0.108). A lactate peak was established in the vitreous of 11 glaucoma patients. Conclusion Determining increased Glx/Cr ratios in both the vitreous and LGB of glaucoma patients, supports the theory of apoptosis in the etiopathogenesis of glaucoma. The MRS method, which can measure biochemical structures and metabolites of tissues, and also shows on a single spectrum, may be a new and non-invasive method for confirming the diagnosis of glaucoma and the role of apoptosis in the etiopathogenesis of glaucoma. Eye (2012) 26, 1044-1051; doi:10.1038/eye.2012.84; published online 25 May 2012en_US
dc.description.sponsorshipInonu University Scientific Research Projecten_US
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Project and presented as a poster in ASCRS 2010 meeting, Boston, USA and awarded with the 'Special Interest' prize.en_US
dc.identifier.doi10.1038/eye.2012.84
dc.identifier.endpage1051en_US
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue8en_US
dc.identifier.pmid22627479en_US
dc.identifier.scopus2-s2.0-84864849247en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1044en_US
dc.identifier.urihttps://doi.org/10.1038/eye.2012.84
dc.identifier.urihttps://hdl.handle.net/11616/95770
dc.identifier.volume26en_US
dc.identifier.wosWOS:000307726000006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofEyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectglaucomaen_US
dc.subjectglutamateen_US
dc.subjectMR spectroscopyen_US
dc.subjectapoptosisen_US
dc.titleEvaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary studyen_US
dc.typeArticleen_US

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