Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage

Basit Öğe Kaydı
dc.authoridAYDIN, Mehmet Şerif/0000-0002-6393-1465
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridTOK, Olgu Enis/0000-0002-4899-9146
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidAYDIN, Mehmet Şerif/JJF-6163-2023
dc.authorwosidTok, Olgu Enis/HGE-3451-2022
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidAYDIN, Mehmet Serif/B-4818-2015
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidElbe, Hulya/D-5261-2015
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorCetin, A.
dc.contributor.authorTaslidere, E.
dc.contributor.authorElbe, H.
dc.contributor.authorAtes, B.
dc.contributor.authorTok, O. E.
dc.contributor.authorAydin, M. S.
dc.date.accessioned2024-08-04T20:43:13Z
dc.date.available2024-08-04T20:43:13Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. METHODS: Rats were divided into 5 groups: Ethanol, Olive oil, CCl4, CCl4+Melatonin (CCl4+Mel), CCl4+Quercetin. Rats were sacrificed and livers were removed for being evaluated by histopathological, immunohistochemical and biochemical methods. RESULTS: In CCl4 group, vacuolization, vascular congestion, haemorrhage, necrosis, and inflammatory infiltration were identified. The mean tissue MDA level was increased, whereas GSH level and SOD and CAT activities were decreased in comparison with ethanol and olive oil groups. MDA levels were decreased in CCl4+Quercetin and CCl4+Mel groups versus CCl4 group. CAT activity of CCl4+Mel group was higher than that of CCl4 and CCl4+Quercetin groups. The mean tissue GSH level of CCl4+Mel group versus CCl4 group was significantly increased. CONCLUSIONS: By the means of histopathological examination, we suggest that both agents are beneficial against necrotic and apoptotic cell death during steatosis. Thus, melatonin and quercetin might be beneficial in the improvement of hepatic steatosis by supporting conventional therapy in humans (Tab. 1, Fig. 5, Ref. 53). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2017_066
dc.identifier.endpage354en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue6en_US
dc.identifier.pmid28664744en_US
dc.identifier.scopus2-s2.0-85021388777en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_066
dc.identifier.urihttps://hdl.handle.net/11616/97869
dc.identifier.volume118en_US
dc.identifier.wosWOS:000405064300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidanten_US
dc.subjectmelatoninen_US
dc.subjectquercetinen_US
dc.subjectliveren_US
dc.titleTherapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damageen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu