Synthesis, structural and thermal characterizations and in vitro cytotoxic activities of new cyclotriphosphazene derivatives

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dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridTekin, Çiğdem/0000-0001-9038-1924
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidGörgülü, Ahmet Orhan/AAQ-4282-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidGörgülü, Ahmet Orhan/W-1964-2018
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.contributor.authorKoran, Kenan
dc.contributor.authorTekin, Cigdem
dc.contributor.authorCaliskan, Eray
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-08-04T20:43:14Z
dc.date.available2024-08-04T20:43:14Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the cytotoxic effects of the newly synthesized cyclotriphosphazene derivatives on A2780 (ovarian), PC-3 and LNCaP (prostate) cancer cell lines. 4'-hydroxy-substituted-chalcone compounds (2-8) were reacted with diphenyl-cyclotriphosphazene (DPP) in the presence of acetone/K2CO3 in order to obtain novel cyclotriphosphazene compounds (DPP 2-8). The structures of DPP2-8 were characterized by MALDI-TOF mass spectrometry, FT-IR, elemental analysis, H-1, C-13-APT, and P-31 NMR measurements. The thermal properties of all phosphazene compounds have been studied after synthesis and characterization procedure. The cytotoxic effects of DPP 2-8 were examined primarily by applying the MTT method based on the measurement of mitochondrial activity. In this regard, several phosphazene compounds have shown high chemotherapeutic effect at low dose (p < 0.05). When the cytotoxic effects of DPP 2-8 at doses of 1, 5, 25, 50 and 100 mu M on A2780 cells were examined, it was observed that DPP-3, DPP-4, DPP-5 and DPP-7 were more effective than other derivatives suggested by their high Log IC50 values (p < 0.05). The compounds DPP 2-8 possess cytotoxic activity against PC-3 and LNCaP cells (especially compounds DPP-4 and DPP-5, p < 0.05).en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [115Z101]en_US
dc.description.sponsorshipThis work was supported financially by The Scientific & Technological Research Council of Turkey (TUBITAK) (Project Number: 115Z101).en_US
dc.identifier.doi10.1080/10426507.2017.1315420
dc.identifier.endpage1011en_US
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85021828193en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1002en_US
dc.identifier.urihttps://doi.org/10.1080/10426507.2017.1315420
dc.identifier.urihttps://hdl.handle.net/11616/97880
dc.identifier.volume192en_US
dc.identifier.wosWOS:000416787800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPhosphorus Sulfur and Silicon and The Related Elementsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclotriphosphazeneen_US
dc.subjectcytotoxic activitiesen_US
dc.subjectchalcone-phosphazeneen_US
dc.subjectcancer cell linesen_US
dc.titleSynthesis, structural and thermal characterizations and in vitro cytotoxic activities of new cyclotriphosphazene derivativesen_US
dc.typeArticleen_US

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