Measurement of Heavy Metal and Antioxidant-Oxidant Levels in Tissues Obtained From Three Different Localizations of Explant Hepatectomy of Patients With Hepatocellular Carcinoma

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSarici, Kemal Baris
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorDogan, Ufuk Gunay
dc.contributor.authorKucukakcali, Zeynep
dc.contributor.authorGarzali, Ibrahim Umar
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. To reveal any difference in terms of heavy metal and antioxidant/oxidant levels of liver tissues obtained from 3 different locations of hepatectomy specimens of patients with Methods. Total hepatectomy materials of patients who underwent liver transplantation for HCC were objects of this study. Three liver tissue samples were obtained from each material, one from HCC tissue, one adjacent from the border of HCC, and one at least 3 cm distant from HCC, each 10 & POUND; 10 mm in diameter. Samples are preserved at -70 & DEG;C. Levels of heavy metals (As, Cd, Cu, Mn, Pb, Se, and Zn) and oxidant-antioxidant parameters (catalase, glutathione perand disulphid) are measured. Results. This study included 22 patients (18 men, 4 women with an age range of 3 to 66 years. There were significant differences in terms of Cd, Pb, Zn, GSHPx, SOD, nitric oxide, and native thiol levels between liver tissues derived from 3 different locations. Cd, Pb, and Zn levels were significantly different in tumor tissues, whereas GSHPx and SOD levels were significantly different in tumor and neighboring tissues. Nitric oxide levels were relatively different in tumor tissues compared with tumor-neighboring tissues. Native thiol levels differed significantly in tumor tissues compared with tissues distant from tumor. Conclusions. The aim of this study is unique in medical literature, which reveals that the amount of heavy metals and antioxidant/oxidant accumulation are variable in the same liver tissue in different locations because of multiple and yet unknown factors.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2018-1314]en_US
dc.description.sponsorshipThis survey study was supported by Inonu University Scientific Research Projects Coordination Unit (Project No: TSA-2018-1314) . Author contributions: Koc C, Akbulut S, Sarici KB, and Karabu-lut E collected data; Akbulut S and Kucukakcali Z performed sta-tistical analysis; Uremis MM and Turkoz Y performed biochemical analysis; Dogan UG measured tissue heavy metal levels; Akbulut S and Garzali IU wrote the manuscript; Akbulut S and Yilmaz S projected development and reviewed final version.en_US
dc.identifier.doi10.1016/j.transproceed.2022.11.013
dc.identifier.endpage1266en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid36604253en_US
dc.identifier.scopus2-s2.0-85146018346en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1262en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2022.11.013
dc.identifier.urihttps://hdl.handle.net/11616/101105
dc.identifier.volume55en_US
dc.identifier.wosWOS:001032946400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssayen_US
dc.subjectCadmiumen_US
dc.subjectCanceren_US
dc.subjectRedoxen_US
dc.titleMeasurement of Heavy Metal and Antioxidant-Oxidant Levels in Tissues Obtained From Three Different Localizations of Explant Hepatectomy of Patients With Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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