Colchicine Protects against Hyperoxic Lung Injury in Neonatal Rats

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dc.authoridOGUZ, SUNA SERIFE/0000-0002-1870-0983
dc.authoridERDEVE, OMER/0000-0002-3193-0812
dc.authoridUysal, Bulent/0000-0003-1254-9749
dc.authorwosidOGUZ, SUNA SERIFE/GWZ-7382-2022
dc.authorwosidTALIM, BERIL/I-9103-2013
dc.authorwosidERDEVE, Omer/W-1480-2017
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorTalim, Beril
dc.contributor.authorUysal, Bulent
dc.contributor.authorErdeve, Omer
dc.contributor.authorOguz, Serife Suna
dc.contributor.authorDilmen, Ugur
dc.date.accessioned2024-08-04T20:36:05Z
dc.date.available2024-08-04T20:36:05Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Bronchopulmonary dysplasia (BPD) is characterized by inflammation, fibrosis and mucosal necrosis, which leads to emphysematous coalescence of alveoli. Objective: We tested whether prophylaxis with colchicine, an anti-inflammatory, antioxidant and antifibrotic drug, would decrease the severity of lung injury in an animal model of BPD. Methods: Twenty-five rat pups were divided into three groups: control (n = 8), hyperoxia (n = 7), and hyperoxia + colchicine (n = 10). The hyperoxia groups were exposed to >95% oxygen from day 1 to 10 of life. On day 10, the animals were sacrificed and the lungs were processed for histology and biochemical analysis. Lung morphology was assessed by the mean linear intercept (MLI), a measure of alveolar size. The degree of lung inflammation and antioxidant capacity were assessed by quantifying lung homogenate tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), malondialde-hyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels. Results: Colchicine significantly decreased lung damage as determined by the MLI in the c groups (p < 0.01). The median level of lung MDA was significantly higher in the hyperoxia group compared with the control group (p < 0.05) and the colchicine-treated group (p < 0.05). Lung homogenate SOD and GSH-Px activities in the colchicine-treated group were significantly higher than in the hyperoxia group (p < 0.05). Furthermore, colchicine-treated pups had lower lung homogenate TNF-alpha and IL-1 beta levels compared with the hyperoxia group (p < 0.05). Conclusions: Colchicine has favorable effects on alveolarization as well as inflammation and oxidative stress markers in an animal model of BPD. Copyright (C) 2012 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000341424
dc.identifier.endpage269en_US
dc.identifier.issn1661-7800
dc.identifier.issn1661-7819
dc.identifier.issue4en_US
dc.identifier.pmid22922655en_US
dc.identifier.scopus2-s2.0-84865281049en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.1159/000341424
dc.identifier.urihttps://hdl.handle.net/11616/95776
dc.identifier.volume102en_US
dc.identifier.wosWOS:000311261100006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNeonatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectColchicineen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectHyperoxiaen_US
dc.titleColchicine Protects against Hyperoxic Lung Injury in Neonatal Ratsen_US
dc.typeArticleen_US

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