Assessment of Liver Regeneration in Patients Who Have Undergone Living Donor Hepatectomy for Living Donor Liver Transplantation

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridDalda, Yasin/0000-0002-0701-8399
dc.authoridÖĞÜT, ZEKİ/0000-0002-7698-9586
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authoridKUCUKAKCALI, ZEYNEP/0000-0001-7956-9272
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidDalda, Yasin/HJY-1580-2023
dc.authorwosidÖĞÜT, ZEKİ/IZP-6632-2023
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidSAHIN, TEVFIK TOLGA/W-2539-2017
dc.contributor.authorSatilmis, Basri
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorDalda, Yasin
dc.contributor.authorTuncer, Adem
dc.contributor.authorKucukakcali, Zeynep
dc.contributor.authorOgut, Zeki
dc.date.accessioned2024-08-04T20:53:30Z
dc.date.available2024-08-04T20:53:30Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Inflammation and the associated immune pathways are among the most important factors in liver regeneration after living donor hepatectomy. Various biomarkers, especially liver function tests, are used to show liver regeneration. The aim of this study was to evaluate the course of liver regeneration following donor hepatectomy (LDH) by routine and regeneration-related biomarkers. Method: Data from 63 living liver donors (LLDs) who underwent LDH in Inonu University Liver Transplant Institute were prospectively analyzed. Serum samples were obtained on the preoperative day and postoperative days (POD) 1, 3, 5, 10, and 21. Regenerative markers including alfa-fetoprotein (AFP), des carboxy prothrombin (DCP), ornithine decarboxylase (ODC), retinol-binding protein 4 (RBP4), and angiotensin-converting enzyme isotype II (ACEII) and liver function tests including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and total bilirubin levels were all analyzed. Results: The median age of the LLDs was 29.7 years and 28 LLDs were female. Eight LLDs developed postoperative complications requiring relaparotomy. The routine laboratory parameters including AST (<0.001), ALT (<0.001), ALP (<0.001), and total bilirubin (<0.001) showed a significant increase over time until postoperative day (POD) 3. For the regeneration-related parameters, except for the RBP4, all parameters including ACEII (p = 0.006), AFP (p = 0.002), DCP (p = 0.007), and ODC (p = 0.002) showed a significant increase in POD3. The regeneration parameters showed a different pattern of change. In right-lobe liver grafts, ACEII (p = 0.002), AFP (p = 0.035), and ODC (p = 0.001) showed a significant increase over time. DCP (p = 0.129) and RBP4 (p = 0.335) showed no significant changes in right-lobe liver grafts. Conclusions: Regenerative markers are increased in a sustained fashion following LDH. This is more prominent following right-lobe grafts which are indicative of progenitor-associated liver regeneration.en_US
dc.identifier.doi10.3390/vaccines11020244
dc.identifier.issn2076-393X
dc.identifier.issue2en_US
dc.identifier.pmid36851123en_US
dc.identifier.scopus2-s2.0-85149106975en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/vaccines11020244
dc.identifier.urihttps://hdl.handle.net/11616/101197
dc.identifier.volume11en_US
dc.identifier.wosWOS:000940093300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofVaccinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver transplantationen_US
dc.subjectliving donor hepatectomyen_US
dc.subjectliver regenerationen_US
dc.subjectliver progenitor cellsen_US
dc.titleAssessment of Liver Regeneration in Patients Who Have Undergone Living Donor Hepatectomy for Living Donor Liver Transplantationen_US
dc.typeArticleen_US

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