What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?

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dc.authoridİLKBAHAR, Fatih/0000-0002-7964-3433
dc.authoridMertoglu, Cuma/0000-0003-3497-4092
dc.authoridHUYUT, Mehmet Tahir/0000-0002-2564-991X
dc.authorwosidİLKBAHAR, Fatih/KOD-0668-2024
dc.authorwosidMertoglu, Cuma/A-3506-2017
dc.contributor.authorHuyut, Mehmet Tahir
dc.contributor.authorHuyut, Zubeyir
dc.contributor.authorIlkbahar, Fatih
dc.contributor.authorMertoglu, Cuma
dc.date.accessioned2024-08-04T20:51:36Z
dc.date.available2024-08-04T20:51:36Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Odds ratios of the parameters affecting one-month mortality were calculated by running multiple-logistic-regression analysis. The cut off values and diagnostic efficiencies of the parameters that posed a risk for mortality were obtained via receiver operating curve analysis. It was determined that the C-reactive protein (CRP), D-dimer, procalcitonin, erythrocyte-sedimentation-rate (ESR), troponin values were at abnormal levels until death occurred in the patients who died. In addition, the procalcitonin levels were consistently high in patients who died. The patients who died generally had a sustained increase in their leukocyte and neutrophil levels and biochemical variables, and an ongoing decrease in lymphopenia and eosinopenia levels. Although significant changes were observed in liver function tests, cardiac troponin, hemogram values, kidney function tests and parameters related to inflammation in deceased patients, high ESR, international-normalized-ratio (INR), prothrombin-time (PT), CRP, D-dimer, ferritin and red-cell-distribution width (RDW) values, respectively, were the most effective predictive mortality risk biomarkers of COVID-19. In addition, neutrophilia, leukocytosis, thrombocytopenia, erythrocytopenia were other risk predictors of mortality. Indicators was found in this study can be successfully used to predict mortality from COVID-19.en_US
dc.identifier.doi10.1016/j.intimp.2022.108542
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid35063753en_US
dc.identifier.scopus2-s2.0-85123001278en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2022.108542
dc.identifier.urihttps://hdl.handle.net/11616/100420
dc.identifier.volume105en_US
dc.identifier.wosWOS:000793200000005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectMortality risk indicatorsen_US
dc.subjectRoutine laboratory characteristicsen_US
dc.subjectHypercoagulationen_US
dc.subjectLeukocytosisen_US
dc.subjectErythrocytopeniaen_US
dc.titleWhat is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?en_US
dc.typeArticleen_US

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