Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress

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dc.authoridKuyumcu Savan, Ebru/0000-0002-8851-0907
dc.authoridKAYMAZ, MUSTAFA BAHADIR/0000-0002-0033-898X
dc.authoridReis, AlessanRSS/0000-0001-8486-7469
dc.authorwosidAbacıoğlu, Nurettin/AAW-9568-2020
dc.authorwosidKuyumcu Savan, Ebru/E-3430-2019
dc.contributor.authorBerk, Ahmet
dc.contributor.authorYllmaz, Ismet
dc.contributor.authorAbacioglu, Nurettin
dc.contributor.authorKaymaz, Mustafa Bahadir
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorSavan, Ebru Kuyumcu
dc.date.accessioned2024-08-04T20:47:07Z
dc.date.available2024-08-04T20:47:07Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The flowering parts of Gentiana olivieri, known as 'Afat' in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression. The purpose of this study is to investigate the antidepressant effect of G. olivieri ethanol extract (GOEE) in a chronic mild stress-induced rat model, which was used to mimic a depressive state in humans, and to compare the effect with that of imipramine. Methods: Male Sprague-Dawley rats were randomly divided into six groups: control, stress, treated with imipramine (positive control) and treated with GOEE at three different (200, 500, 1000 mg/kg) doses groups. The rats in all groups, except the control group, were exposed to chronic mild stress. At the end of the 3-week experimental period, biochemical and behavioral parameters were examined. Results: The results showed that treatment with GOEE or imipramine significantly improved rats' sucrose consumption which was diminished by chronic mild stress, restored serum levels of corticosterone and proinflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)), prevented the increase of liver index of rats. Moreover, in the hippocampus tissue, decreased serotonin and noradrenaline levels were significantly increased by treatment with GOEE or imipramine, and antioxidant parameters (thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and glutathione (GSH)) were significantly improved by treatment with GOEE though not with imipramine. Conclusion: The data demonstrate that G. olivieri may exert its antidepressant activity by improving monoaminergic system disorders, and by favorably affecting the antioxidant, inflammatory and the endocrine mechanisms.en_US
dc.description.sponsorshipInonu University, Scientific Research Project (BAP) [2015/36]en_US
dc.description.sponsorshipThis study was supported by Inonu University, Scientific Research Project (BAP), with project number of [2015/36].en_US
dc.identifier.doi10.1080/19932820.2020.1725991
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.issue1en_US
dc.identifier.pmid32048914en_US
dc.identifier.scopus2-s2.0-85079334315en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/19932820.2020.1725991
dc.identifier.urihttps://hdl.handle.net/11616/99178
dc.identifier.volume15en_US
dc.identifier.wosWOS:000512840400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofLibyan Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntidepressanten_US
dc.subjectGentiana olivierien_US
dc.subjectchronic mild stressen_US
dc.subjectraten_US
dc.subjectsucrose consumptionen_US
dc.titleAntidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stressen_US
dc.typeArticleen_US

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