Protective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagy

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dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridYilmaz, Nesibe/0000-0002-5527-8507
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidYilmaz, Nesibe/JFK-5834-2023
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorYildiz, Azibe
dc.contributor.authorTanbek, Kevser
dc.contributor.authorKisaoglu, Aysegul
dc.contributor.authorYilmaz, Umit
dc.contributor.authorKose, Evren
dc.date.accessioned2024-08-04T20:56:03Z
dc.date.available2024-08-04T20:56:03Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA significant clinical condition known as testicular torsion leads to permanent ischemic damage to the testicular tissue and consequent loss of function in the testicles. In this study, it was aimed to evaluate the protective effects of Astaxanthin (ASTX) on testicular damage in rats with testicular torsion/detorsion in the light of biochemical and histopathological data. Spraque Dawley rats of 21 were randomly divided into three groups; sham, testicular torsion/detorsion (TTD) and astaxanthin + testicular torsion/detorsion (ASTX + TTD). TTD and ASTX + TTD groups underwent testicular torsion for 2 hours and then detorsion for 4 hours. Rats in the ASTX + TTD group were given 1 mg/kg/day astaxanthin by oral gavage for 7 days before torsion. Following the detorsion process, oxidative stress parameters and histopathological changes in testicular tissue were evaluated. Malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly decreased in the ASTX group compared to the TTD group, while superoxide dismutase (SOD), glutathione (GSH) and total antioxidant status (TAS) levels were increased ( p < 0.05). Moreover, histopathological changes were significantly reduced in the group given ASTX ( p < 0.0001). It was determined that ASTX administration increased Beclin-1 immunoreactivity in ischemic testicular tissue, while decreasing caspase-3 immunoreactivity ( p < 0.0001). Our study is the first to investigate the antiautophagic and antiapoptotic properties of astaxanthin after testicular torsion/detorsion based on the close relationship of Beclin-1 and caspase-3 in ischemic tissues. Our results clearly demonstrate the protective effects of ASTX against ischemic damage in testicular tissue. In ischemic testicular tissue, ASTX contributes to the survival of cells by inducing autophagy and inhibiting the apoptosis.en_US
dc.identifier.doi10.22514/j.androl.2024.005
dc.identifier.endpage37en_US
dc.identifier.issn1698-031X
dc.identifier.issue1en_US
dc.identifier.pmid38735875en_US
dc.identifier.scopus2-s2.0-85192920902en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.22514/j.androl.2024.005
dc.identifier.urihttps://hdl.handle.net/11616/101996
dc.identifier.volume22en_US
dc.identifier.wosWOS:001223263300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofRevista Internacional De Andrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTestisen_US
dc.subjectTorsionen_US
dc.subjectAstaxanthinen_US
dc.subjectOxidative stressen_US
dc.subjectBeclin-1en_US
dc.subjectCaspase-3en_US
dc.titleProtective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagyen_US
dc.typeArticleen_US

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