Quantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity

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dc.authoridARABACI, Turan/0000-0003-3869-4557
dc.authoridGoren, Ahmet Ceyhan/0000-0002-5470-130X
dc.authoridCarikci, Sema/0000-0003-3657-9926
dc.authorwosidARABACI, Turan/AAQ-3885-2020
dc.authorwosidGoren, Ahmet Ceyhan/G-1562-2017
dc.authorwosidCarikci, Sema/AAL-8875-2020
dc.contributor.authorCarikci, Sema
dc.contributor.authorKilic, Turgut
dc.contributor.authorOzer, Zuleyha
dc.contributor.authorDirmenci, Tuncay
dc.contributor.authorArabaci, Turan
dc.contributor.authorGoren, Ahmet C.
dc.date.accessioned2024-08-04T21:00:57Z
dc.date.available2024-08-04T21:00:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, quantities of some phenolics; caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin in the directly methanol (M1), chloroform (C), acetone (Ac) and methanol (M2) extratcs obtained from Origanum laevigatum Boiss. from Turkey were investigated via liquid chromatography and tandem mass spectrometry (LC-MS/MS). Curcumin was used as an internal standard. Caffeic acid, chlorogenic acid, rosmarinic acid and gallic acid were determined as the most abundant phenolic acids in the studied extracts using LC-MS/MS. In LC-MS/MS measurements relative standard deviations (RSD %) for caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin were found to be 8.04, 5.21, 5.45, 3.73, 5.44, 4.85, 5.47 and 6.57 % respectively. For the investigated analytes, the correlation coefficient was found in the range of 0.9803 to 0.9981. Furthermore, antioxidant properties of the extracts were determined based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), beta-carotene linoleic acid and cupric (Cu2+) ion reducing power assay (CUPRAC). Acetone (Ac) and methanol (M2) extracts showed high activity in all test assays due to their high concentration of rosmarinic acid, caffeic acid and gallic acid in the extracts. (C) 2018 ACG Publications. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [113Z710]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 113Z710].en_US
dc.identifier.doi10.25135/jcm.21.18.11.1115
dc.identifier.endpage127en_US
dc.identifier.issn1307-6183
dc.identifier.issue2en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.25135/jcm.21.18.11.1115
dc.identifier.urihttps://hdl.handle.net/11616/103965
dc.identifier.volume12en_US
dc.identifier.wosWOS:000454236700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofJournal of Chemical Metrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOriganumen_US
dc.subjectphenolicsen_US
dc.subjectLC-MS/MSen_US
dc.subjectvalidationen_US
dc.subjectantioxidant activityen_US
dc.subjectrosmarinic aciden_US
dc.titleQuantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activityen_US
dc.typeArticleen_US

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