Bioavailability file: Amlodipine
| dc.authorscopusid | 14032701900 | |
| dc.authorscopusid | 56094749300 | |
| dc.authorscopusid | 56095245300 | |
| dc.authorscopusid | 56666885900 | |
| dc.contributor.author | Kaynak M.S. | |
| dc.contributor.author | Bogacz A. | |
| dc.contributor.author | Stelmasi?ski M. | |
| dc.contributor.author | Şahin S. | |
| dc.date.accessioned | 2024-08-04T20:01:01Z | |
| dc.date.available | 2024-08-04T20:01:01Z | |
| dc.date.issued | 2011 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Amlodipine (AML), a third-generation dihydropiridin, is a long-acting L-calcium channel blocker used in the treatment of hypertension and angina pectoris. It exerts its effects by blocking the voltage-dependent L-calcium channels and binding to both dihydropiridin and nondihydropiridin binding sites. AML is well absorbed (96%) after oral administration and its bioavailability is between 64-90%. Its volume of distribution is about 16 to 21 L/kg and protein binding is 98% after oral administration. AML is extensively metabolized in the liver and its elimination from the plasma is biphasic with a terminal half-life of 30 to 50 h. It is excreted by renal route about 60%. According to Biopharmaceutics Classification System, AML is classified as class I drug by WHO. In this review physicochemical properties, pharmacology, analytical methods, pharmacokinetics and bioavailability of amlodipine are discussed. | en_US |
| dc.identifier.endpage | 222 | en_US |
| dc.identifier.issn | 1300-4182 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopus | 2-s2.0-84897432947 | en_US |
| dc.identifier.scopusquality | Q3 | en_US |
| dc.identifier.startpage | 207 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/91196 | |
| dc.identifier.volume | 36 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Ankara University | en_US |
| dc.relation.ispartof | Fabad Journal of Pharmaceutical Sciences | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Amlodipine | en_US |
| dc.subject | Bioavailability | en_US |
| dc.subject | Biopharmaceutics Classification System (BCS) | en_US |
| dc.subject | Pharmacokinetics | en_US |
| dc.title | Bioavailability file: Amlodipine | en_US |
| dc.type | Review Article | en_US |
