Effects of valproic acid and levetiracetam monotherapy on balance functions in patients with generalized epilepsy

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dc.authoridÇolak, Sanem Can/0000-0002-7566-7964
dc.authoridAdiguzel, Ahmet/0000-0001-5197-7063
dc.authorwosidÇolak, Sanem Can/ADG-5437-2022
dc.authorwosidAdiguzel, Ahmet/GPG-3954-2022
dc.contributor.authorCengiz, Deniz Ugur
dc.contributor.authorColak, Sanem Can
dc.contributor.authorOzdemir, Emre Akgun
dc.contributor.authorAdiguzel, Ahmet
dc.date.accessioned2024-08-04T20:55:00Z
dc.date.available2024-08-04T20:55:00Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: It is reported that antiepileptic drugs have an effect on balance functions. The aim of the study was to evaluate and compare the effects of valproic acid and levetiracetam monotherapy on balance functions in patients with generalized epilepsy using objective test methods. Methods: The study included 43 generalized epilepsy patients aged 18-60 years, including 20 patients receiving valproic acid monotherapy, 23 patients receiving levetiracetam monotherapy, and 25 healthy individuals as controls, in the Neurology Clinic of a university hospital in eastern Turkey. The demographic data form was filled out and the Video Head Impulse Test and Vestibular Evoked Myogenic Potentials test were performed. Results: Statistically significant differences were obtained between the groups in lateral, posterior, and anterior semicircular canal gains and RALP and LARP asymmetry values in the V-HIT test (p < 0.05). Statistically significant differences were obtained between the groups in P1, N1 latency and asymmetry values in the C-VEMP test and in N1, P1 latency, amplitude, and asymmetry values in the o-VEMP test (p < 0.05). Conclusion: Valproic acid and levetiracetam may affect the vestibulocular and vestibulocolic reflex pathways negatively. In this cohort, valproic acid had more pronounced adverse effects on balance functions as compared to levetiracetam.en_US
dc.identifier.doi10.1016/j.yebeh.2024.109622
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.pmid38219606en_US
dc.identifier.scopus2-s2.0-85182872667en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.yebeh.2024.109622
dc.identifier.urihttps://hdl.handle.net/11616/101773
dc.identifier.volume151en_US
dc.identifier.wosWOS:001166546500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEpilepsy & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneralized epilepsyen_US
dc.subjectValproic aciden_US
dc.subjectLevetiracetamen_US
dc.subjectBalanceen_US
dc.subjectVideo head impulse testen_US
dc.subjectVestibular evoked myogenic potentials testen_US
dc.titleEffects of valproic acid and levetiracetam monotherapy on balance functions in patients with generalized epilepsyen_US
dc.typeArticleen_US

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