The efficacy and reliability of sequential adjuvant anthracycline-based chemotherapy and weekly paclitaxel regimen in human epidermal growth factor receptor 2 negative breast cancer: A retrospective analysis of a multicentre study

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dc.authoridElkıran, Emin Tamer/0000-0001-6681-7249
dc.authoridAytekin, Aydın/0000-0002-7001-3945
dc.authoridKaplan, Muhammet Ali/0000-0003-0882-0524
dc.authoridSAKIN, Abdullah/0000-0003-2538-8569
dc.authorwosidGumus, Mahmut/HTO-4176-2023
dc.authorwosidElkıran, Emin Tamer/ABI-8192-2020
dc.authorwosidBerk, Veli/IXE-0017-2023
dc.authorwosidAytekin, Aydın/AAL-7959-2020
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorOruc, Zeynep
dc.contributor.authorGumus, Mahmut
dc.contributor.authorOzaydm, Sukru
dc.contributor.authorElkiran, Emin Tamer
dc.contributor.authorDine, Nur Sener
dc.contributor.authorSakin, Abdullah
dc.date.accessioned2024-08-04T20:46:01Z
dc.date.available2024-08-04T20:46:01Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To analyze the reliability and the effectiveness of chemotherapy and prognostic factors for survival in patients with HER2 (human epidermal growth receptor 2) negative early-stage breast cancer treated with adjuvant sequential anthracycline-based chemotherapy and paclitaxel. Methods: This analysis retrospectively evaluated the medical records of 756 HER2 negative early-stage breast cancel-patients who received adjuvant sequential anthracycline-based chemotherapy and weekly paclitaxel in 15 medical oncology centers in Turkey between 2008-2015. Estrogen receptor (ER), progesterone receptor (PR), HER2, age, tumor size and grade, nodal status, perineural and lymphatic invasion, disease-free survival (DFS) and overall survival (OS) were analyzed. Results: The median patient age was 50 years (22-82). Median follow up period was 46 months (13-82). The rates of recurrence and death detected in this period were 14.8% and 7.4%, respectively.Median OS and PFS were not reached in this period. Five-year DFS and OS rates were 87% and 89%, respectively. Age (OR:0.35, 95%CI 0.12-0.96, p=0.04), PR status (OR:.0.44, 95%CI 0.18-1, p=0.05), lymphatic invasion (OR:.2.6, 95%CI 0.97-7.4, p=0.05) were independent prognostic factors.Most common grade 3-4 toxicides were fatigue (6.7%), neutropenia (1.7%) and nausea (1.3%). Neutropenic fever developed in 1.8% o f the patients and peripheral neuropathy in 16.9%. Dose reduction was necessary for 10%of the patients due to grade 3-4 toxicity, whereas postponement of chemotherapy was neccessary for 7% of the patients. Conclusions: This multicentric retrospective study confirmed that sequential adjuvant therapy with anthracycline-based chemotherapy and paclitaxel for HER2 negative breast cancer is an effective and reliable regimen.en_US
dc.identifier.endpage1086en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue3en_US
dc.identifier.pmid31424664en_US
dc.identifier.scopus2-s2.0-85067671245en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1081en_US
dc.identifier.urihttps://hdl.handle.net/11616/98840
dc.identifier.volume24en_US
dc.identifier.wosWOS:000471764000029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpaclitaxelen_US
dc.subjectanthracyclineen_US
dc.subjectadjuvanten_US
dc.subjectbreast canceren_US
dc.titleThe efficacy and reliability of sequential adjuvant anthracycline-based chemotherapy and weekly paclitaxel regimen in human epidermal growth factor receptor 2 negative breast cancer: A retrospective analysis of a multicentre studyen_US
dc.typeArticleen_US

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