Relationship of serum calprotectin, angiopoietin-1, and angiopoietin-2 levels with coronary collateral circulation in patients with stable coronary artery disease

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dc.authoridİNANDIKLIOĞLU, NİHAL/0000-0001-7137-3929
dc.authoridINANDIKLIOGLU, NIHAL/0000-0001-7137-3929
dc.authoridHidayet, Şıho/0000-0002-4103-9345
dc.authorwosidİNANDIKLIOĞLU, NİHAL/AAA-5776-2021
dc.authorwosidTuran, Yaşar/AAL-6084-2020
dc.authorwosidINANDIKLIOGLU, NIHAL/AFX-4462-2022
dc.authorwosidHidayet, Şıho/ABI-2256-2020
dc.contributor.authorDemir, Vahit
dc.contributor.authorEde, Huseyin
dc.contributor.authorErcan, Mujgan
dc.contributor.authorTuran, Yasar
dc.contributor.authorHidayet, Siho
dc.contributor.authorInandiklioglu, Nihan
dc.contributor.authorErbay, Ali Riza
dc.date.accessioned2024-08-04T20:47:03Z
dc.date.available2024-08-04T20:47:03Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND In patients with chronic stable coronary artery disease (CAD), well-developed coronary collateral circulation (CCC) is known to reduce long-term mortality. AIMS The objective of this study was to determine the relationship of serum calprotectin (S100A8 /S100A9), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) concentrations with CCC in patients with stable CAD. METHODS This prospective cross-sectional study included 147 patients with stable angina pectoris. The Cohen-Rentrop classification was used to assess CCC. Patients were divided into 2 groups: with poor CCC (Cohen-Rentrop score, 0-1; n = 79) and with good CCC (Cohen-Rentrop score, 2-3; n = 68). Serum calprotectin, Ang-1, and Ang-2 concentrations were compated between groups. RESULTS Compared with the group with good CCC, serum calprotectin and Ang-1 levels were higher (P <0.01 and P<0.001, respectively), while serum Ang-2 levels were lower (P<0.01) in the poor-CCC group. C-reactive protein levels showed a moderate positive correlation with calprotectin levels (r = 0.359; P <0.001). In a multivariate regression analysis, only calprotectin (P <0.05) and Ang-1 (P <0.05) were found to be independent predictors of good and poor CCC. CONCLUSIONS Our study showed that Ang-2 levels were lower, while serum calprotectin and Ang-1 levels were higher, in patients with stable CAD and poor CCC regardless of the complexity and severity of coronary arteriosclerosis. If these results are confirmed in future studies, calprotectin may be considered a useful biomarker for guiding anti-ischemic treatment.en_US
dc.description.sponsorshipDirectorate of Scientific Research Projects, Bozok University [6602a--TF/16-40]en_US
dc.description.sponsorshipThis study was supported by the Directorate of Scientific Research Projects, Bozok University (project decision no., 6602a--TF/16-40; to VD).en_US
dc.identifier.doi10.33963/KP.15023
dc.identifier.endpage1162en_US
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue12en_US
dc.identifier.pmid31617500en_US
dc.identifier.scopus2-s2.0-85077016595en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1155en_US
dc.identifier.urihttps://doi.org/10.33963/KP.15023
dc.identifier.urihttps://hdl.handle.net/11616/99117
dc.identifier.volume77en_US
dc.identifier.wosWOS:000503501600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPolskie Towarzystowo Kardiologiczneen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectangiopoietin-1en_US
dc.subjectangiopoietin-2en_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcoronary collateral circulationen_US
dc.subjectserum calprotectinen_US
dc.titleRelationship of serum calprotectin, angiopoietin-1, and angiopoietin-2 levels with coronary collateral circulation in patients with stable coronary artery diseaseen_US
dc.typeArticleen_US

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