Potential role of dietary ?-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatum

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dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridOzen, Oguz Aslan/0000-0003-2521-0031
dc.authorwosidSongur, Ahmet/IWM-3343-2023
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidOzen, Oguz Aslan/AHE-6215-2022
dc.contributor.authorSarsilmaz, M
dc.contributor.authorSongur, A
dc.contributor.authorÖzyurt, H
dc.contributor.authorKus, I
dc.contributor.authorÖzen, OA
dc.contributor.authorÖzyurt, B
dc.contributor.authorSögüt, S
dc.date.accessioned2024-08-04T20:13:33Z
dc.date.available2024-08-04T20:13:33Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOmega-3 (omega-3) is an essential fatty acid (EFA) found in large amounts in fish oil. It contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. Evidences support the hypothesis that schizophrenia may be the result of increased reactive oxygen species mediated neuronal injury. Recent reports also suggest the protective effect of omega-3 EFA against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in antioxidant enzyme and oxidant parameters in the corpus striatum (CS) of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 were decapitated under ether anesthesia, and CS was removed immediately. Thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels as well as total superoxide dismutase (t-SOD) and xanthine oxidase (XO) enzyme activities in the CS were measured. Rats treated with omega-3 EFA had significantly lower values of TBARS (P < 0.001), NO (P < 0.002) and XO (P < 0.005) whereas higher values of t-SOD enzyme activity (P < 0.002) than the control rats. These results indicate that omega-3 EFA rich fish oil diet reduces some oxidant parameters in CS. This may be revealed by means of reduced CS TBARS levels as an end product of lipid peroxidation of membranes in treated rats. Additionally, reduced XO activity and NO levels may support this notion. On the other hand, although the mechanism is not clear, omega-3 EFA may indirectly enhance the activity of antioxidant enzyme t-SOD. Taken together, this preliminary animal study provides strong support for a therapeutic effect of omega-3 EFA supplemented to classical neuroleptic regimen in the treatment of schizophrenic symptoms and tardive dyskinesia. (C) 2003 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0952-3278(03)00107-8
dc.identifier.endpage259en_US
dc.identifier.issn0952-3278
dc.identifier.issn1532-2823
dc.identifier.issue4en_US
dc.identifier.pmid12907135en_US
dc.identifier.scopus2-s2.0-0345304875en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.1016/S0952-3278(03)00107-8
dc.identifier.urihttps://hdl.handle.net/11616/93691
dc.identifier.volume69en_US
dc.identifier.wosWOS:000185414500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofProstaglandins Leukotrienes and Essential Fatty Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectomega-3 essential fatty acidsen_US
dc.subjectcorpus striatumen_US
dc.subjectlipid peroxidationen_US
dc.subjectxanthine oxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectnitric oxideen_US
dc.titlePotential role of dietary ?-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatumen_US
dc.typeArticleen_US

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