Resveratrol a red wine constituent polyphenol protects gastric tissue against the oxidative stress in cholestatic rats
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dig Dis Sci., 0–0.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis.
Açıklama
Dig Dis Sci., 0–0.
Anahtar Kelimeler
Resveratrol biliary, Cirrhosis, Malondialdehyde, Reduced glutathione
Kaynak
Dig Dis Sci., 0–0.
WoS Q Değeri
Scopus Q Değeri
Cilt
0
Sayı
0
Künye
Kırımlıoğlu, V., Ara, C., Yılmaz, M., Özgör, D., Işık, B., Söğütlü, G., … Bay Karabulut, A. (2006). Resveratrol A Red Wine Constituent Polyphenol Protects Gastric Tissue Against The Oxidative Stress İn Cholestatic Rats . Dig Dis Sci., 0–0.
