Antioxidant properties of propofol and erythropoietin after closed head injury in rats

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dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidSARIÇİÇEK, Vahap/JRW-2455-2023
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorOzturk, E
dc.contributor.authorDemirbilek, S
dc.contributor.authorBut, AK
dc.contributor.authorSaricicek, V
dc.contributor.authorGulec, M
dc.contributor.authorAkyol, O
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:14:54Z
dc.date.available2024-08-04T20:14:54Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractReactive oxygen species play a role during brain injury due to closed head trauma. Enzymatic or nonenzymatic antioxidants may protect brain tissue against oxidative damage. The present study was performed to assess the changes of endogenous indices of oxidative stress in serum from rats subjected to head trauma and whether treatment with propofol and/or erythropoietin (EPO) modifies the levels of endogenous indices of oxidative stress. For these purposes, female Wistar Albino rats were divided into five groups: nontraumatic sham group, trauma performed control, trauma with propofol (i.p.), trauma with EPO (i.p.) and trauma with propofol and EPO performed study groups. At the end of the experimental procedure, blood was taken by cardiac puncture to determine superoxide dismutase (SOD) and xanthine oxidase (XO) activities as well as malondialdehyde (MDA) and nitric oxide (NO) levels in serum. Serum NIDA level of control traumatic brain injury (TBI) group was significantly higher than sham operation group (p < 0.012). Serum NIDA levels in propofol, EPO and propofol+EPO groups were found to be decreased in comparison with control group (p < 0.039, p < 0.030 and p < 0.018, respectively). Serum NO level was found to be increased in TBI group, but difference was not statistically significant when compared to sham-operated group (p=0.092). Propofol, EPO and propofol+EPO administration efficiently reduced serum NO levels to reach sham-operated group (p < 0.002, p < 0.001 and p < 0.015, respectively). These results suggested that acute administration of both propofol and EPO altered the indices of oxidative stress similarly against brain injury due to trauma. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2005.04.028
dc.identifier.endpage925en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-23144436905en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage920en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2005.04.028
dc.identifier.urihttps://hdl.handle.net/11616/94035
dc.identifier.volume29en_US
dc.identifier.wosWOS:000231513700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterythropoietinen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectpropofolen_US
dc.subjecttraumatic brain injuryen_US
dc.titleAntioxidant properties of propofol and erythropoietin after closed head injury in ratsen_US
dc.typeReview Articleen_US

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