Assessment of embryotoxic effects of cadmium, lead and copper on Xenopus laevis

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dc.authorscopusid12760269900
dc.authorscopusid55405078900
dc.authorscopusid7005095273
dc.contributor.authorGüngördü A.
dc.contributor.authorBirhanli A.
dc.contributor.authorOzmen M.
dc.date.accessioned2024-08-04T20:00:39Z
dc.date.available2024-08-04T20:00:39Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis work evaluated the effects of selected metals on embryos using Frog Embryo Teratogenesis Assay- Xenopus (FETAX). Besides FETAX parameters, changes in several biomarkers were studied as early signs of intoxication on Xenopus laevis tadpoles. The acute effects of metals were investigated by using the activity of the enzymes glutathione S-transferase (GST), glutathione reductase, acetylcholinesterase (AChE), carboxylesterase, lactate dehydrogenase, aspartate aminotranferase, and alanine aminotranferase. In the FETAX test, 96-h LC50s were determined as 1.6 mg/L, 96.1 mg/L, and 1.37 mg/L for Cd, Pb, and Cu, respectively. Also, teratogenic index (TI) of each metal was estimated as 1.1, 1.22, and 0.52 for Cd, Pb, and Cu, respectively. The TI showed that tested metals were not teratogenic in X. laevis embryos according to ASTM values. The comparison of selected metals on selected enzyme activities was expected to give useful indications for the proper use of biochemical responses as biomarkers. © by PSP.en_US
dc.identifier.endpage2535en_US
dc.identifier.issn1018-4619
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-78650347216en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2528en_US
dc.identifier.urihttps://hdl.handle.net/11616/90897
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkersen_US
dc.subjectFETAXen_US
dc.subjectMalformationsen_US
dc.subjectMetalsen_US
dc.subjectXenopus laevisen_US
dc.titleAssessment of embryotoxic effects of cadmium, lead and copper on Xenopus laevisen_US
dc.typeArticleen_US

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