Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

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dc.authoridCiplak, Baris/0000-0002-9981-9264
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridCOSKUN, Ebru INCI/0000-0003-4402-3725
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authorwosidCiplak, Baris/AAB-2086-2021
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidCOSKUN, Ebru INCI/ABI-8238-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorGul, Mehmet
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCoskun, Ebru Inci
dc.contributor.authorSahin, Nurhan
dc.contributor.authorGul, Semir
dc.contributor.authorBastemur, Ayse Gulcin
dc.date.accessioned2024-08-04T20:45:25Z
dc.date.available2024-08-04T20:45:25Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n=23), patients with endometrial hyperplasia (Group 2, n=21) and patients with endometrial cancer (Group 3, n=20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.en_US
dc.description.sponsorshipBAP committee of the Inonu University [2016/74]en_US
dc.description.sponsorshipThis study was supported by the BAP committee of the Inonu University Scientific Research Projects (2016/74).en_US
dc.identifier.doi10.1177/0300060518777944
dc.identifier.endpage3716en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue9en_US
dc.identifier.pmid29998764en_US
dc.identifier.scopus2-s2.0-85053680936en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3709en_US
dc.identifier.urihttps://doi.org/10.1177/0300060518777944
dc.identifier.urihttps://hdl.handle.net/11616/98474
dc.identifier.volume46en_US
dc.identifier.wosWOS:000443978100020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNEDD4Len_US
dc.subjectendometrial canceren_US
dc.subjectubiquitinen_US
dc.subjecttumorigenesisen_US
dc.subjectendometrial hyperplasiaen_US
dc.subjectimmunohistochemistryen_US
dc.titleNeural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial canceren_US
dc.typeArticleen_US

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