A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder

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dc.authoridKılıç, Osman Hasan Tahsin/0000-0001-7070-6808
dc.authoridAltindag, Abdurrahman/0000-0001-5531-4419
dc.authoridAksoy, İhsan/0000-0001-8426-2072
dc.authoridKılıç, Osman Hasan Tahsin/0000-0001-7070-6808
dc.authorwosidKılıç, Osman Hasan Tahsin/AAK-2864-2020
dc.authorwosidAltindag, Abdurrahman/AAG-6463-2020
dc.authorwosidAksoy, İhsan/ABF-1270-2020
dc.authorwosidKılıç, Osman Hasan Tahsin/ABG-3359-2022
dc.contributor.authorAksoy, Ihsan
dc.contributor.authorGucyetmez, Volkan
dc.contributor.authorKilic, Osman Hasan Tahsin
dc.contributor.authorUnal, Ahmet
dc.contributor.authorAltindag, Abdurrahman
dc.date.accessioned2024-08-04T20:10:32Z
dc.date.available2024-08-04T20:10:32Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Changes in oxidative metabolism are increasingly gaining attention as an important factor for many medical illnesses such as carcinogenesis and psychiatric disorders including ADHD. Only a handful of studies have investigated the possible relation between adult attention deficit and hyperactivity disorder (A-ADHD) and oxidative stress. However, we found no research about its relation to oxidative DNA damage. Methods: The study comprised of 43 A-ADHD patients and 30 healthy controls. Serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured and compared in a cross-sectional design. Results: No difference was observed in terms of oxidative stress and oxidative DNA damage across groups. Patients with comorbid psychiatric diagnosis had significantly increased TOS and OSI levels than patients with A-ADHD alone, although their comorbidity was in remission. Conclusion: According to our results, oxidative balance among adult ADHD patients were not impaired, this was discordant with the majority of the findings of the studies performed in children and adolescents and animals. Oxidative stress may not have a specific role in the etiopathogenesis of ADHD in adults. It is more plausible that other factors such as comorbid disorders affect and confound oxidative stress in adult population.en_US
dc.identifier.doi10.5455/PBS.20190626065655
dc.identifier.endpage85en_US
dc.identifier.issn2636-834X
dc.identifier.issue2en_US
dc.identifier.startpage80en_US
dc.identifier.trdizinid420279en_US
dc.identifier.urihttps://doi.org/10.5455/PBS.20190626065655
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/420279
dc.identifier.urihttps://hdl.handle.net/11616/92848
dc.identifier.volume10en_US
dc.identifier.wosWOS:000640976500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofPsychiatry and Behavioral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult ADHDen_US
dc.subjectOxidative Balanceen_US
dc.subject8-hydroxy-2 '-deoxyguanosineen_US
dc.titleA Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorderen_US
dc.typeArticleen_US

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