Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.contributor.authorAslan, Mehmet
dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Nilufer
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorSimsek, Yavuz
dc.date.accessioned2024-08-04T20:35:57Z
dc.date.available2024-08-04T20:35:57Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 +/- A 8.3 vs. 9.6 +/- A 5.9 ng/ml, P = 0.001) and nesfatin-1 levels were found lower (5.5 +/- A 8.1 vs. 8.1 +/- A 23.9 ng/ml, P = 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 +/- A 4.3 and 8.2 +/- A 1.9 ng/ml, P = 0.618) and nesfatin-1 levels (5.4 +/- A 4.0 and 6.2 +/- A 10.3 ng/ml, P = 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.en_US
dc.identifier.doi10.1007/s12020-011-9577-8
dc.identifier.endpage429en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3en_US
dc.identifier.pmid22203468en_US
dc.identifier.scopus2-s2.0-84862677281en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-011-9577-8
dc.identifier.urihttps://hdl.handle.net/11616/95695
dc.identifier.volume41en_US
dc.identifier.wosWOS:000303584900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectApelin-36en_US
dc.subjectNesfatin-1en_US
dc.subjectInsulinen_US
dc.titleCord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitusen_US
dc.typeArticleen_US

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