Association of CagA-positive Helicobacter pylori infection with severity of obstructive sleep apnea syndrome

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dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridYildirim, Oguzhan/0000-0001-8254-0104
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.contributor.authorYildirim, Oguzhan
dc.contributor.authorBali, Ilhan
dc.contributor.authorTulubas, Feti
dc.contributor.authorMete, Rafet
dc.contributor.authorTopcu, Birol
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorCagin, Yasir Furkan
dc.date.accessioned2024-08-04T20:42:32Z
dc.date.available2024-08-04T20:42:32Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: To investigate the association between Helicobacter pylori cytotoxin-associated gene-A (CagA) status and the severity of OSA syndrome in infected patients. Methods: Ninty-six patients with obstructive sleep apnea syndrome (OSAS) and 30 age-and sex-matched control subjects with no history of OSA or gastrointestinal complaints were included in the study. Patients' apnea-hypopnea index (AHI) was determined by polysomnography (PSG), and serum H. Pylori IgG and cytotoxin-associated gene-A IgG was assayed by enzyme-linked immunosorbent assay (ELISA). Based on their AHI score, subjects were assigned to one of three groups: a control group (AHI<5), a mild-moderate OSAS group (AHI >= 5 and < 30), and a severe OSAS group (AHI >= 30). Results: The prevalence of H. pylori IgG seropositivity was significantly higher in the severe OSAS group compared to the mild-moderate OSAS group [ 29 (90.6%) patients versus 41 (64%) patients, (p=0.007)]. In addition, CagA seropositivity was present in 10 control patients (58.8%), 23 mild-moderate OSAS patients (56%), and 25 severe OSAS patients (86.2%). There was a significantly higher prevalence of CagA seropositivity in the severe OSAS group compared to mild-moderate OSAS group (p=0.027). There was no significant difference in CagA seropositivity between the mild-moderate OSAS group and the control group (p=0.059). Conclusion: Our findings suggest that H. pylori strains expressing CagA may be considered a risk factor in the severity of OSAS.en_US
dc.identifier.endpage871en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84978976264en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage867en_US
dc.identifier.urihttps://hdl.handle.net/11616/97430
dc.identifier.volume27en_US
dc.identifier.wosWOS:000388456100049en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers Indiaen_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectCytotoxin-associated antigenen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.titleAssociation of CagA-positive Helicobacter pylori infection with severity of obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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