The effect of melatonin on acetylsalicylic acid induced kidney and testis damage
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Human & Experimental Toxicology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and
testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total
of 40 rats were randomly divided into the following 5 groups (n ¼ 8): group 1: control, not given any drug;
group 2: only 200 mg/kg ASA was given; group 3: 5 mg/kg melatonin was given 45 min before administering
200 mg/kg ASA; group 4: 5 mg/kg melatonin was given 45 min after administering 200 mg/kg ASA; and group
5: only 5 mg/kg melatonin was given. The histopathological changes and the biochemical findings; such as malondialdehyde
(MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced
glutathione (GSH), and blood urea nitrogen (BUN) as well as serum creatinine (Cr) levels were evaluated. ASA
significantly increased MDA levels in both kidney and testis, whereas it significantly decreased the values of
SOD, CAT, GPX, and GSH in kidney and CAT levels in testis. Melatonin significantly decreased MDA levels
in kidney and ameliorated it in testis, whereas it caused elevation in the levels of antioxidants. BUN and Cr
levels were higher after ASA, whereas these levels were diminished after melatonin administration. The
improvement obtained by melatonin on ASA-induced histological alterations was more prominent when it was
used after ASA in kidney and before ASA in testis. In this study, we demonstrated the beneficial effect of
melatonin on high-dose ASA-related pathology of kidney and testis for the first time.
Açıklama
Anahtar Kelimeler
Acetylsalicylic acid, Melatonin, Kidney, Testis, Rat
Kaynak
Human & Experimental Toxicology
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
4
Künye
Altıntaş, R. Polat, A. Parlakpınar, H. Vardı, N. Beytur, A. Oğuz, F. Sağır, M. Yıldız, A. Duran, Z. R. (2014). The effect of melatonin on acetylsalicylic acid induced kidney and testis damage. Human & Experimental Toxicology, 33(4), 383–395.
