Tumor-Like Lesions in the Craniovertebral Junction: A Case Series, Systematic Review, and Meta-Analysis

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dc.contributor.authorPop, Maria Mihaela
dc.contributor.authorBouros, Dragos
dc.contributor.authorKlimko, Artsiom
dc.contributor.authorPop, Laura Ancuta
dc.contributor.authorTopal, Paula
dc.contributor.authorTopal, Anil
dc.contributor.authorFlorian, Ioan Stefan
dc.date.accessioned2026-04-04T13:31:11Z
dc.date.available2026-04-04T13:31:11Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Tumor-like lesions at the craniovertebral junction mimic tumors in clinical presentation and imaging. Our study focuses on three common developmental pathologies-epidermoids, dermoids and neurenteric cysts. Methods: We conducted a retrospective analysis of a case series and a meta-analysis of 170 patients from 119 reports. Results: Neurenteric cysts predominated (81.2%). Anterior cysts were linked to neurenteric cysts, while posterior ones correlated with dermoid/epidermoid cysts (p < 0.001). Complications occurred in 27.2% of cases, with cranial nerve paresis being the most common. Most patients had excellent outcomes (75.2%) with low recurrence rates (12%). Dermoid cysts were more associated with anomalies (p < 0.001). Among 138 neurenteric cyst cases, 15 experienced recurrence, with predictors including ages 51-60 and over 70, subtotal resection, complications, and poor outcomes (p < 0.001). Cysts with total resection were significantly less likely to adhere to surrounding brain tissue (p < 0.001). CSF diversion was correlated with older age (p = 0.010) and various complications (p < 0.001). Age affected outcomes, and the hydrocephalus was linked to poor outcomes (p = 0.002). Conclusions: This meta-analysis underscores the importance of total resection in minimizing recurrence rates and emphasizes meticulous preoperative planning and imaging. Our results indicate that rim enhancement (p = 0.047) and poor outcome (p = 0.007) are significant factors associated with recurrence. Additionally, associated anomalies, as well as the patient's age and overall health, significantly influence the surgical outcomes and the likelihood of recurrence.
dc.identifier.doi10.3390/cancers16162788
dc.identifier.issn2072-6694
dc.identifier.issue16
dc.identifier.orcid0000-0002-2499-3399
dc.identifier.orcid0000-0001-7127-0946
dc.identifier.orcid0000-0002-5806-0220
dc.identifier.orcid0009-0000-7810-1539
dc.identifier.pmid39199561
dc.identifier.scopus2-s2.0-85202482290
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/cancers16162788
dc.identifier.urihttps://hdl.handle.net/11616/108636
dc.identifier.volume16
dc.identifier.wosWOS:001306979800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofCancers
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectcraniovertebral junction (CVJ)
dc.subjecttumor-like lesions
dc.subjectneurenteric cyst
dc.subjectepidermoid cysts
dc.subjectdermoid cysts
dc.subjectsystematic review
dc.subjectmeta-analysis
dc.titleTumor-Like Lesions in the Craniovertebral Junction: A Case Series, Systematic Review, and Meta-Analysis
dc.typeReview

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