Expression of claudin-4 and ?-catenin in gastric premalignant lesions

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dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridKarincaoglu, Melih/0000-0002-9727-5128
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.contributor.authorSeckin, Y.
dc.contributor.authorArici, S.
dc.contributor.authorHarputluoglu, M.
dc.contributor.authorYonem, O.
dc.contributor.authorYimaz, A.
dc.contributor.authorOzer, H.
dc.contributor.authorKarincaoglu, M.
dc.date.accessioned2024-08-04T20:32:16Z
dc.date.available2024-08-04T20:32:16Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and study aims : Abnormal expression of claudin-4 and beta-catenin play a role in carcinogenesis. The purpose of the present study was to examine claudin-4 and beta-catenin expression in normal and precancerous gastric mucosa. Patients and methods : Endoscopic biopsy specimens [normal gastric mucosa (n = 22), intestinal metaplasia (n = 24), dysplasia (n = 18), Helicobacter pylori (H. pylori)-associated chronic gastritis (n = 32) and remnant gastric mucosa (n = 18)] obtained from different 114 patients were examined by immunohistochemistry. Results : Claudin-4 expression was present in 94.4% of dysplasia, 87.5% of intestinal metaplasia, 62.5% H. pylori-associated chronic gastritis, and 88.9% remnant gastric mucosa but only 18.2% of normal gastric mucosa biopsies. Decreased expression of beta-catenin was present in 27.8% of dysplasia, 8.3% of intestinal metaplasia, 15.6% of H. pylori-associated chronic gastritis, and 22.2% of remnant gastric mucosa biopsies, but was not present in normal gastric mucosa. When compared with normal gastric mucosa, there was a significant difference in claudin-4 expression in all groups (P < 0.05), but a significant difference was detected in dysplasia and remnant gastric mucosa for beta-catenin (P < 0.05). Conclusions : Our results suggest that claudin-4 expression is upregulated in premalignant gastric alterations. (Acta gastroenterol. belg., 2009, 72, 407-412).en_US
dc.identifier.endpage412en_US
dc.identifier.issn0001-5644
dc.identifier.issue4en_US
dc.identifier.pmid20163034en_US
dc.identifier.scopus2-s2.0-76049083750en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://hdl.handle.net/11616/94969
dc.identifier.volume72en_US
dc.identifier.wosWOS:000273799600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectclaudin-4en_US
dc.subjectbeta-cateninen_US
dc.subjectgastric epithelial dysplasiaen_US
dc.subjectintestinal metaplasiaen_US
dc.subjectHelicobacter pylorien_US
dc.titleExpression of claudin-4 and ?-catenin in gastric premalignant lesionsen_US
dc.typeArticleen_US

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