Design of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Properties

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.contributor.authorDenkbas, Emir Baki
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorGulgen, Selam
dc.contributor.authorTaslidere, Elif
dc.date.accessioned2024-08-04T20:41:38Z
dc.date.available2024-08-04T20:41:38Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDeveloping biocompatible tissue adhesives with high adhesion properties is a highly desired goal of the tissue engineering due to adverse effects of the sutures. Therefore, our work involves synthesis, characterization, adhesion properties, protein adsorption, in vitro biodegradation, in vitro and in vivo biocompatibility properties of xylose-based semisynthetic polyurethane (NPU-PEG-X) bioadhesives. Xylose-based semisynthetic polyurethanes were developed by the reaction among 4,4'-methylenebis(cyclohexyl isocyanate) (MCI), xylose and polyethylene glycol 200 (PEG). Synthesized polyurethanes (PUs) showed good thermal stability and high adhesion strength. The highest values in adhesion strength were measured as 415.0 +/- 48.8 and 94.0 +/- 2.8 kPa for aluminum substrate and muscle tissue in 15% xylose containing PUs (NPU-PEG-X-15%), respectively. The biodegradation of NPU-PEG-X-15% was also determined as 19.96 +/- 1.04% after 8 weeks of incubation. Relative cell viability of xylose containing PU was above 86%. Moreover, 10% xylose containing NPU-PEG-X (NPU-PEG-X-10%) sample has favorable tissue response, and inflammatory reaction between 1 and 6 weeks implantation period. With high adhesiveness and biocompatibility properties, NPU-PEG-X can be used in the medical field as supporting materials for preventing the fluid leakage after abdominal surgery or wound closure.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey [TUBITAK-TBAG-111T104]en_US
dc.description.sponsorshipThis study was supported by the grants to B. Ates from The Scientific and Technical Research Council of Turkey (TUBITAK-TBAG-111T104).en_US
dc.identifier.doi10.1021/acsami.5b12279
dc.identifier.endpage4466en_US
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.issue7en_US
dc.identifier.pmid26824739en_US
dc.identifier.scopus2-s2.0-84962528552en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4456en_US
dc.identifier.urihttps://doi.org/10.1021/acsami.5b12279
dc.identifier.urihttps://hdl.handle.net/11616/97255
dc.identifier.volume8en_US
dc.identifier.wosWOS:000371105800023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Applied Materials & Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectxyloseen_US
dc.subjectpolyurethaneen_US
dc.subjecttissue adhesiveen_US
dc.subjectbiocompatibilityen_US
dc.subjectsemisynthetic materialsen_US
dc.titleDesign of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Propertiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu