Hemoglobin A1c-related histologic characteristics of symptomatic carotid plaques

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridTecellioglu, Mehmet/0000-0002-8381-9630
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidTecellioglu, Mehmet/AAA-3220-2021
dc.contributor.authorTecellioglu, M.
dc.contributor.authorAlan, S.
dc.contributor.authorKamisli, S.
dc.contributor.authorTecellioglu, F. S.
dc.contributor.authorKamisli, O.
dc.contributor.authorOzcan, C.
dc.date.accessioned2024-08-04T20:45:50Z
dc.date.available2024-08-04T20:45:50Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The aims of our study were to compare the histomorphological characteristics of carotid plaques and glycosylated hemoglobin (HbA1c), which are risk factors for ischemic stroke, in patients who underwent carotid endarterectomy for carotid artery stenosis. Moreover, we aimed to identify the structures that were histologically affected by symptomatic carotid plaques in cases with elevated HbA1c. Materials and Methods: A total of 64 patients who presented with ischemic stroke and had not previously been diagnosed with diabetes were retrospectively evaluated. All stroke risk factors were reviewed. Carotid plaques were graded separately by two different pathologists through microscopic assessment of the following parameters: plaque rupture, lipid core, fibrous cup thickness, inflammation, intraplaque hemorrhage, thrombus, calcification, necrotic core, and neovascularization. An HbA1c value <6.3% was accepted as normal or indicative of prediabetes (group 1), whereas patients with values ranging between 6.3-7.4%, 7.5-8.4%, and 8.4% were categorized into the effectively controlled (group 2), less effectively controlled (group 3), and uncontrolled (group 4) groups, respectively. Results: The mean age of the patients was 73.0 4.5 years in group 1, 69.7 2.3 years in group 2, 66.0 8.5 years in group 3, and 62.7 7.1 years in group 4. A negative correlation was present between age and HbA1c. Smoking, hypertension, low-density lipoprotein cholesterol levels, and triglyceride levels were not significantly different among the four groups. According to the HbA1c classifications, the fibrous cup thickness was 2.64 0.3 mm in group 1, 1.85 0.4 mm in group 2, 1.68 0.5 mm in group 3, and 1.45 0.6 mm in group 4. The fibrous cup became thinner as the HbA1c value increased. Other parameters of unstable carotid plaques did not differ among the HbA1c groups. Conclusions: Increased HbA1c values seem to contribute to plaque instability through the formation of a thin fibrous cup. Thus, of the carotid artery plaque parameters including fibrous cup thickness, plaque rupture, lipid core, inflammation, intraplaque hemorrhage, thrombus, calcification, necrotic core, and neovascularization, fibrous cup thickness is the only histomorphological feature that affected by HbA1c.en_US
dc.description.sponsorshipInonu University Scientific Project Unit [2016-64]en_US
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Project Unit (Project no. 2016-64).en_US
dc.identifier.doi10.4103/njcp.njcp_386_18
dc.identifier.endpage398en_US
dc.identifier.issn1119-3077
dc.identifier.issue3en_US
dc.identifier.pmid30837429en_US
dc.identifier.scopus2-s2.0-85062595173en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_386_18
dc.identifier.urihttps://hdl.handle.net/11616/98711
dc.identifier.volume22en_US
dc.identifier.wosWOS:000460891100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid plaqueen_US
dc.subjectcarotid plaque histologyen_US
dc.subjectfibrous cup thicknessen_US
dc.subjectHbA1cen_US
dc.titleHemoglobin A1c-related histologic characteristics of symptomatic carotid plaquesen_US
dc.typeArticleen_US

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